[Conférence] E. MIGNOT - Cause de la narcolepsie

Conférence : Hommage à Michel Jouvet Lien de la conférence : https://www.academie-sciences.fr/fr/C... 00:00:00 Introduction 00:01:01 Human narcolepsy-cataplexy, a REM sleep and wakefulness disorder 00:07:56 Genetic epidemiology is consistent with Autoimmunity 00:13:30 Many canine narcolepsy cases are genetically transmitted as a single gene 00:15:58 Hypocretin receptor [Hcrtr2] Mutations in genetic forms of narcolepsy in canines 00:17:33 Truncated receptors in canine narcolepsy 00:17:55 1998: Hypocretin/orexins discovered 00:18:45 Hypocretin deficiency in sporadic, HLA positive adolescent onset narcolepsy cases 00:20:31 Normal hypocretin and receptors 00:20:47 Hypocretin deficiency and receptors 00:21:11 Next question: Why are hypocretin-producing cells missing in human narcolepsy? 00:22:32 Manhattan GWAS in 5,500 narcolepsy 00:23:40 One environmental factor: flu 00:24:16 HLA-peptide-TCR 00:25:35 Hypocretin Agonist 00:26:05 Conclusion 00:27:14 Our inspiration 00:27:60 Questions © Académie des sciences - Tous droits réservés Vidéo réalisée par Weconext®