How to Treat Pseudomonas Infections: What Clinicians Get Wrong

Why is Pseudomonas aeruginosa so frustrating to treat? If you’ve struggled with interpreting susceptibility reports or choosing the right empiric antibiotics, this video is for you. In this practical, no-fluff overview, I’ll walk you through: • Why Pseudomonas is intrinsically resistant to so many antibiotics • Which antibiotics actually have a chance of working • What “I” (Increased exposure) means in a susceptibility report • Common pitfalls with aminoglycosides and carbapenems • When to use combination therapy (and when to stop) • How to approach empiric vs targeted treatment • The key logic behind antibiotic selection that many clinicians miss Whether you're a hospitalist, intensivist, or infectious disease trainee, this short video will help you make smarter, faster antibiotic decisions for one of the most difficult gram-negatives out there. Note: Links to courses and additional materials are currently unavailable. The website is undergoing changes and updates. Thank you for your understanding. DISCLAIMER: Please, always keep in mind that my videos are intended for educational purposes only. The content of my videos is NOT medical advice. I do not practice medicine over the Internet. If you are a patient and have any questions about your health, please talk to your doctor. CHAPTERS: 00:00 What infections does Pseudomonas aeruginosa cause? 00:28 What antibiotics is Pseudomonas resistant to, and why? 01:19 What are antipseudomonal antibiotics? 02:36 What does “I” mean in antibiotic susceptibility reports for Pseudomonas? 03:36 How do you choose the optimal antibiotic for Pseudomonas infections? 05:08 Empiric therapy for suspected Pseudomonas: monotherapy or combination therapy?