Ketone Metabolic Therapy – Applications, Methods, and Biomarker Monitoring - Dom D'Agostino - #CoSci

[Heads up -- if you haven't already, consider coming to Las Vegas for our very next #CoSci conference this February 8th and 9th, 2025. For more details, visit CoSci.org] Dr. Dominic D’Agostino presents a compelling overview of his pioneering research in ketogenic metabolic therapy, focusing on its applications in health optimization, military resilience, and treating a broad range of conditions. He emphasizes the therapeutic potential of exogenous ketones and ketogenic diets in enhancing mitochondrial efficiency, managing neurological disorders, and exploring new biomarkers. Dr. D’Agostino integrates personal anecdotes, clinical studies, and practical tools for monitoring ketosis and metabolic health, advocating for personalized strategies to maximize the benefits of therapeutic ketosis. 0:00 – Introduction to Dr. Dominic D’Agostino’s Work 0:07 – Welcoming Remarks and Acknowledgments 0:32 – Overview of Research Funding and Disclosures 1:13 – Role at University of South Florida and Research Labs 2:09 – Applications of Ketogenic Metabolic Therapy 3:00 – Biomarker Monitoring and Personalized Strategies 3:55 – Research on Ketone Therapy Across Model Systems 5:01 – Anti-Seizure Effects of Ketones 6:00 – Human Trials Using Ketones in Hyperbaric Chambers 7:05 – NASA Missions and Ketogenic Research Applications 7:41 – Scientific Validity of the Ketogenic Diet 8:46 – Rapid Growth of Ketogenic Research 9:11 – Emerging Research on Psychiatric Disorders 10:26 – Clinical Trials with Ketone Supplements 12:24 – Benefits of Exogenous Ketones in Various Diseases 13:12 – Methods to Sustain Therapeutic Ketosis 15:00 – Energy and Signaling Effects of Ketones 17:26 – Importance of Self-Monitoring Tools 19:05 – Key Biomarkers for Metabolic Health 27:00 – Exploring the Role of LDL and APOB in Health 31:20 – Practical Recommendations and Emerging Applications 32:58 – Concluding Thoughts and Acknowledgments