Progenitor cells regenerate heart muscle and repel scar-forming fibroblasts

Our latest research published in Nature Cell Biology reveals the mechanisms that enable human progenitor cells to migrate to the site of cardiac injury and regenerate heart cells, while simultaneously repelling fibroblasts to prevent fibrotic scarring. 0:55. Background 2:50. HVP form functional ventricular cardiomyocytes 3:06. Ex vivo co-culture with native NHP-LV 5:05. HVPs migrate and remuscularise acutely damaged myocardium 6:36. HVPs are chemoattracted to sites of cardiac injury 9:26. HVPs remuscularise chronic scars of chronic ischaemia in vivo. 13:08. Conclusion ------------------------------------------------------------ Global site: https://www.astrazeneca.com/ Careers site: https://careers.astrazeneca.com/ Follow us: Twitter:   / astrazeneca   LinkedIn:   / astrazeneca   Instagram:   / astrazeneca   Facebook:   / astrazeneca