How to calculate Partial Correlation in Bioinformatics A Step by Step Guide 📊

Follow the script here https://divingintogeneticsandgenomics... chatomics! In this video, I walk you through the concept of partial correlation and its application in bioinformatics, specifically calculating the partial correlation of two genes' CRISPR dependency scores while controlling for cancer types. I demonstrate how to generate dummy data and perform correlation tests using R, ultimately highlighting the importance of standardizing variables for accurate results. I also present a practical example using CRISPR screening data from cancer cell lines, where I found a correlation of 0.51 between the genes FoxA1 and ESR1 in breast cancer cells. I encourage you to explore the provided data and consider how partial correlation can enhance your analyses in gene relationships. Thank you for watching! #bioinformatics