Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨‍⚕️

#drnajeeb #pharmacology #medicines #adrenergic #drugs # adrenergicdrugs Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨‍⚕️ Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $10 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/... --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 1000+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ 00:00:00 Introduction, Autonomic NS pharmacology, Subtypes 00:05:25 Neurophysiology of sympathetic and parasympathetic nervous system 00:10:30 How sympathetic nervous system activated? Function of hypothalamus and limbic system 00:16:20 Polyneuronal sympathetic descending pathway 00:19:16 Sympathetic outflow, Adrenergic and non-adrenergic receptors, acetylcholine, nor epinephrine 00:25:45 Recap 00:26:15 How nerve endings work? Neurotransmitter synthesis, storage and release 00:30:12 Synthesis of norepinephrine (Tyrosine, DOPA, Dopamine, Norepinephrine) 00:46:46 How norepinephrine release? Depolarization sensitive Calcium channel 00:55:15 Inhibitory function of Alpha 2 receptor 00:58:31 What happens to norepinephrine after its release? 01:07:16 Drugs effect on nerve endings of adrenergic transmission (Metyrosine, Reserpine, Guanethidine, Alpha methyl dopa) 01:29:50 Concept of agonist, antagonist, partial agonist, mixed agonist and antagonist 01:39:38 Adrenoceptor Blocker or antagonist (sympatholytic drugs) Alpha blockers Beta blockers 01:47:56 Recap 01:50:14 sympathomimetic Drugs and its classification 01:53:21 A) Direct acting sympathomimetic drugs 02:11:25 B) Indirect acting sympathomimetic drugs (cocaine, TCA) 02:22:40 Distribution of adrenergic receptors on different body tissues 02:43:23 Changes in body under the influence of adrenergic response 02:44:17 a) Changes in hairs 02:46:41 b) Changes in eyes (pupils, ciliary muscles, lens etc.) 03:01:12 c) Changes in GIT --------------------------------------------------------------------------------------------------------------------------- Adrenergic Agonists are drugs that lead to stimulation of the adrenergic receptors. In doing so, adrenergic agonists generally simulate activation of certain aspects of the sympathetic nervous system and are thus also known as "sympathomimetics". Mechanisms of Action Overview A diverse variety of sympathomimetics exist which operate using distinct mechanisms. In general, these compounds are divided into direct-acting, indirect-acting, or mixed-acting agonists depending on whether they directly activate adrenergic receptors or do so by indirect mechanisms Direct-acting Agonists Direct agonists physically bind the adrenergic receptor and simulate binding of an endogenous ligand. These compounds can be highly specific, activating only certain subtypes of receptors, or can be rather promiscuous. Indirect-acting Agonists Indirect agonists do not physically bind adrenergic receptors. Instead, these compounds indirectly lead to receptor activation through a variety of possible mechanisms which include promoting release of endogenously-stored norepinephrine from presynaptic terminals as well as inhibition of norepinephrine re-uptake and degradation from the synapse. Mixed-acting Agonists Mixed agonists simply refer to those compounds which display both direct and indirect mechanisms of actions. As such, these compounds directly bind adrenergic receptors but also promote the indirect mechanisms described above. --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to perks: Sign up now on our website at https://members.drnajeeblectures.com/...    / @doctornajeeb   Follow us on Facebook :-   / drnajeeb   Follow us on Instagram :-   / drnajeeblectures