A New Treatment for Chronic Hives: Remibrutinib

If antihistamines aren't helping your chronic hives, there's a new treatment option to know about. In this episode of The Itch Review, we break down the REMIX trial, published in the New England Journal of Medicine in March 2025. This study looked at remibrutinib, a new pill for chronic spontaneous urticaria (CSU) that works differently from antihistamines. We walk through how the study was set up, what the results showed, and what side effects to watch for. The FDA approved remibrutinib in September 2025. What you'll learn in this episode: What chronic spontaneous urticaria (CSU) is and why antihistamines don't work for everyone How remibrutinib works as a BTK inhibitor Why researchers ran two identical trials (REMIX-1 and REMIX-2) Key results: about half reached well-controlled disease, about 1 in 3 became completely clear How fast patients saw improvement Safety: what to know about petechiae and other bleeding events DOWNLOAD THE INFOGRAPHIC (https://drive.google.com/file/d/1JIWY...) Thanks to Novartis for sponsoring this episode. This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns. The Itch Review, hosted by Dr. Gupta, Kortney, and Dr. Blaiss, explores allergy and immunology studies, breaking down complex research in conversations accessible to clinicians, patients, and caregivers. Each episode provides key insights from journal articles and includes a one-page infographic in the show notes for easy reference. More from the Allergy & Asthma Network: More Allergy, Asthma & Immunology Innovations Podcast episodes: https://allergyasthmanetwork.org/podc... Latest news articles: https://allergyasthmanetwork.org/news/ Asthma content: https://allergyasthmanetwork.org/what... Allergy content: https://allergyasthmanetwork.org/alle... Eczema content: https://allergyasthmanetwork.org/what... Anaphylaxis content: https://allergyasthmanetwork.org/anap... Related conditions: https://allergyasthmanetwork.org/heal...