만성 B형간염 완치: 베피로비르센(Bepirovirsen) 3상 연구 성공 (2부)

[Turning the Dream of a Hepatitis B Cure into Reality: In-depth Analysis of 'Bepirobirsen' Clinical Results] In this video, we examine in detail the latest clinical research results and the potential for a cure regarding **Bepirobirsen**, which is opening new horizons in the treatment of chronic Hepatitis B, from the perspective of a medical specialist. 1. Why Has a Cure Been Difficult Until Now? The Root of the Virus, cccDNA: Because the viral genes have taken root within the nucleus of liver cells, it has been difficult to completely eliminate them with existing drugs. Immune Evasion Strategy: This is because the virus releases massive amounts of antigens to paralyze our body's immune cells. 2. Bepirobirsen's 'Ultimate Weapon': Dual Mechanism of Action RNA Destruction: By directly locating and cutting the RNA—the blueprint for viral proteins—it blocks viral replication at the source. Reactivation of the Immune System: By drastically lowering antigen levels, it reawakens dormant immune cells and enables them to attack the virus on their own. 3. Remarkable Efficacy Proven by Clinical Studies (B-Clear, B-Sure) Dramatic Improvement in Cure Probability: A functional cure rate of *up to 25%* was recorded in the patient group with surface antigen (HBsAg) levels of 1,000 IU/mL or less. Sustained Treatment Effect: 8 out of 10 cured patients maintained a stable cure status even 2 years after the end of treatment. 4. Combination Therapy to Enhance Synergy Research is actively underway to maximize cure rates through combination therapy with other agents, such as interferon or siRNA, going beyond bepirovirsen monotherapy. 5. Significance of Elevated Liver Enzymes During Treatment Liver enzyme levels (ALT) may temporarily rise during treatment; this is a positive signal, akin to a **'report of victory'**, indicating that immune cells are eliminating virus-infected liver cells. #Bepirobirsen #HepatitisBCure #LiverDisease #Hepatitis #ChronicHepatitisB #ChronicHepatitisC #Cirrhosis #LiverCancer #NamdoGwangju #Antiviral #Viread #Vemlidy #Baraclude #GrayZone #NamdoGwangju #InternalMedicineDoctorHanJeongRyeol #LiverSpecialist #OsteoporosisSpecialist #HepatitisBMedicalInsurance