What is PGT (Preimplantation Genetic Testing)? | Dr.Madhupriya | Fertility Specialist | Chennai

Dr Madhupriya, Fertility Specialist, Nova IVF- Chennai talks about- What is PGT ( Preimplantation Genetic Testing)? After IVF therapy, when the baby was formed, people used to hear phrases like "preimplantation genetic testing," "preimplantation genetic screening," and "preimplantation genetic diagnosis. Normally, it is called PGT, PGS, or PGD. Pre-implantation means the embryo should be fixed in the uterus, which is called implantation. Before the embryo gets fixed in the uterus, a cell is taken through the biopsy method and needed to diagnose it to find that the sperm doesn't have any chromosomal or genetic problems in it. Finding the good embryo and then injecting the embryo inside the uterus is called "IVF with Preimplantation Genetic Testing." There are two types of testing: *PGD - Preimplantation genetic diagnosis- They will need to undergo IVF therapy, which could lead to miscarriages and repeated implantation failures if they find out from the scan reports that their baby has congenital defects for the second time. Even those who use IVF embryos may experience a problem where the embryo sticks to the uterus and they then experience miscarriages or simply unfavourable outcomes if the embryo doesn't fix in the uterus. Recurrent implantation failure is what we call it. *PGS - Pre implantation genetic screening- For certain women, if they see any congenital defects in their unborn child after becoming pregnant—also known as "congenital cardiac defect" or "nuchal translucency"—the baby's neck will be thick, which will cause "choroid plexus cysts" to cause issues with the heart and brain's development. When it occurs repeatedly, a diagnosis is made in order to identify the chromosomal issue. So, for a person with a particular chromosome issue, sperm that is free of any issues will be selected and injected into the uterus. "PGD" is the term for this. Then, for some couples, eggs will get fixed in the uterus. Then the baby will start to grow, but suddenly the heartbeat stops. In this case, a screening test called "PGS" needs to be done. Usually, a baby is born from 46 chromosomes in an embryo, so we will check each and every sperm and ensure that they don't have any chromosomal problems. Then an "euploid embryo" will be used , which is a well-tested embryo. When it is used then, there is a high chance of pregnancy, low miscarriage, and a low chance of pregnancy loss, which has control over 90% of it. Then next, instead of checking all 46 chromosomes, the problematic chromosome can be identified. By selecting the embryo that isn't affected by that chromosome and placing it, it is called "PGD"—"preimplantation genetic diagnosis of a particular chromosomal disorder. So this "preimplantation genetic diagnosis" is done with the 5 day old blastocyst embryo from the IVF procedure, and one cell will be taken from each embryo through biopsy, check the chromosome in all the cells, and select the healthy embryo with no problems. To book an appointment call 1800 103 2229 (Toll Free) https://www.novaivffertility.com/ivf-... Follow us: Facebook:   / novaivffertility   Instagram:   / novaivffertility   YouTube:    / novaivffertility   Twitter:   / nova_ivf   LinkedIn:   / nova-ivf-fertility   #pgt #implantation #genetictesting 0:00 Introduction 0:34 What is Preimplantation Genetic Testing? 1:20 What is Pre Implantation genetic diagnosis? 1:55 What is Recurrent implantation failure? 2:30 What is Pre implantation genetic screening? 4:40 What is preimplantation genetic testing for aneuploidy? 6:00 What is the process behind PGD?