Integrating T-DXd Across HER2+ Care with Drs. Megan Kruse, William Gradishar & Ajaz Khan

How should clinicians integrate T-DXd across the entire HER2-positive breast cancer treatment continuum? Dr. Megan Kruse, Dr. William Gradishar, and Dr. Ajaz Khan discuss the evolving role of trastuzumab deruxtecan (T-DXd) in early-stage and metastatic HER2-positive breast cancer. From DESTINY-Breast11 and DESTINY-Breast05 to first-line metastatic DESTINY-Breast09 strategies, the conversation explores how recent data are reshaping treatment decisions, patient selection, toxicity management, and long-term sequencing approaches. Topics discussed include: • DESTINY-Breast11 and neoadjuvant T-DXd • DESTINY-Breast05 and residual disease management • Pathologic complete response (pCR) outcomes • Selecting patients for neoadjuvant vs adjuvant T-DXd • ILD monitoring and toxicity management • T-DXd sequencing after recurrence • First-line metastatic treatment strategies • DESTINY-Breast09 implications • T-DXd plus pertuzumab in metastatic disease • Quality of life and long-term treatment planning • ctDNA, treatment duration, and future research directions As T-DXd expands across earlier and later stages of HER2-positive breast cancer, clinicians face new opportunities and new questions about how best to maximize outcomes while minimizing toxicity. Subscribe to Community Health Media for more expert oncology discussions, clinical insights, and updates from the latest advances in cancer care. #CommunityHealthMedia #CHM #BreastCancer #HER2Positive #HER2BreastCancer #TDXd #Enhertu #DESTINYBreast11 #DB11 #DESTINYBreast05 #DB05 #DESTINYBreast09 #DB09 #MetastaticBreastCancer #EarlyStageBreastCancer #NeoadjuvantTherapy #AdjuvantTherapy #BreastOncology #MedicalOncology #MeganKruse #WilliamGradishar #AjazKhan – Thanks for watching! Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast... • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o – Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences. We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences. We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcasts Learn more about us here - https://communityhealth.media