On Gender Medicine: The Utah Gender Report with Leor Sapir

Are puberty blockers and cross-sex hormones for gender dysphoric minors supported by strong scientific evidence? Manhattan Institute Senior Fellow Leor Sapir and Society for Evidence-Based Gender Medicine Co-Founder Zhenya Abbruzzese examine the findings of the Utah review on hormonal treatments for minors experiencing gender dysphoria and discusses what the evidence says about pediatric gender care. The conversation explores concerns about research quality, methodological limitations in existing studies, conflicts of interest in medical guidelines, and the challenges of applying evidence-based medicine to one of the most debated topics in modern healthcare. Leor explains why rigorous scientific standards, long-term outcome data, and transparent clinical practices are essential when evaluating medical interventions for children and adolescents. Whether you're interested in gender medicine, healthcare policy, medical ethics, clinical research, or evidence-based healthcare, this episode provides an in-depth analysis of the ongoing debate surrounding puberty blockers, hormone therapy, and treatment protocols for gender dysphoric youth. Get the best of City Journal, delivered weekly: https://www.city-journal.org/email-al... Follow City Journal on X: https://x.com/CityJournal Leor Sapir: https://x.com/LeorSapir 00:00 Introduction to the Utah Review and its claims 02:02 What is evidence-based medicine and why it matters 03:57 The role of systematic reviews in medical research 06:53 The formation and purpose of SEGUM 08:13 Analysis of the Utah Review's methodology 11:56 Conflicts of interest and bias in the review process 14:56 Handling of long-term outcomes and harms 20:01 Epidemiological trends and their omission in the review 27:07 What makes a systematic review trustworthy 32:09 Tools and methods used in evaluating the Utah Review 42:59 Manipulation of study comparators and bias 46:51 Exclusion of studies on harms and long-term effects 54:51 Conflicts of interest among Utah Review authors 01:03:03 Implications for policy and medical practice 01:08:03 Societal and ethical considerations in gender medicine 01:08:58 Conclusion: The need for integrity in medical research