#80 - Epigenetics of exercise adaptation and "muscle memory" with Dr Kevin Murach

Dr Glenn McConell chats with Assistant Professor Kevin Murach who is a rising star from the University of Arkansas, USA. Kevin is an expert on muscle, muscle growth, adaptation to exercise training, “muscle memory”, the regulation of muscle growth and muscle memory and the effect of aging etc. Muscle memory definitely seems real (especially in slow muscle fibers). Looks like epigenetics involved more than changes to muscle fibers nuclei. But more work needs to be done, especially in humans. We had a really great chat. I enjoyed it a lot. A very smart chap. Twitter: @KevinMurachPhD 0:00. Introduction and welcome 2:16. How Kevin got into exercise research 6:53. What is “muscle memory”. 9:15. Human evidence of muscle memory 13:58. Mice models to investigate resistance training 19:30. Training, detraining and retraining 20:35. Comparing rodents and human re their different lifespans 22:30. Evidence for muscle memory in mice after ex training 31:05. Mouse model that has both endurance and strength effects 33:25. Voluntary wheel running: matching the training 35:45. 10% greater hypertrophy with retraining 39:25. Mice slow postural muscles didn’t detrain! 44:45. Mechanisms: epigenetics 49:50. Muscle nuclei and exercise training/muscle memory 1:02:00. Muscle memory and epigenetics in the nuclei 1:05:40. MicroRNA and muscle memory 1:07:30. Epigenetics 1:08:35. Exercise training and each bout of exercise 1:11:20. MicroRNA and muscle memory 1:16:20. Balance of protein synthesis and breakdown 1:20:20. Muscle memory: Endurance vs resistance training 1:21:35. Time course of muscle memory 1:23:55. How much training need to get muscle memory 1:25:18. Specificity of ex training muscle memory 1:26:40. Nature and nuture 1:27:25. Dutch famine and epigenetics 1:28:18. Age and muscle memory 1:29:38. Biological sex and muscle memory 1:30:40. Common misconceptions: use it or lose it 1:31:38. Identical twins 1:32:25. Don’t need to go hard or go home. 1:33:05. Research experts vs influencers etc 1:37:15. Takeaway messages 1:39:44. Do health benefits have a memory too? 1:41:45. Outro Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.100.... Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell   / glenn-mcconell-83475460   ResearchGate: Glenn McConell Email: [email protected] Subscribe to Inside exercise: Spotify: shorturl.at/tyGHL Apple Podcasts: shorturl.at/oFQRU YouTube:    / @insideexercise   Anchor: https://anchor.fm/insideexercise Google Podcasts: shorturl.at/bfhHI Anchor: https://anchor.fm/insideexercise Podcast Addict: https://podcastaddict.com/podcast/402... Not medical advice