Onc Now: AI, Immunotherapy, and the Next Wave of Cancer Trials
In this episode of Onc Now, we explore the challenges of translating early-phase oncology research into meaningful clinical benefit. Our guest discusses why so many promising therapies fail in Phase I–III trials, the complexity of the tumour microenvironment, and the evolving role of biomarkers, AI, and combination strategies in improving success rates. The conversation also highlights advances in cell therapy for solid tumours, the future of precision oncology, and how global factors are shaping cancer research. Timestamps: 00:00 – Introduction 02:37 - Phase 1 trial translation challenge 04:57 – Microenvironment complexity 07:41 - Anti-PD1 combination overcoming resistance 10:55 - First-in-human drug selection improvement 13:30 - AI reducing early trial failure 17:18 - Cell therapy solid tumour barriers 21:00 - Research evolution biomarkers clinical approach 23:28 - Geopolitics funding disruption oncology research 25:52 - Future cancer drug development trends 29:30 - Three wishes oncology future Disclaimer: The opinions expressed in this episode belong to the speakers and do not necessarily represent the opinions of EMJ.
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