Cocaine: Use, Abuse, Overdose, Toxicology.

Cocaine is one of the most dangerous drugs of abuse, but also the most common. Its history dates back thousands of years to the ancient people of South America. If you enjoyed the video, please like and subscribe as it helps the YouTube algorithm tell me what worked well. Leave suggestions for video ideas in the comments! Please note, this video is not medical advice The main effects of cocaine are: Autonomic Central Nervous System Cardiovascular Treatment of cocaine toxicity involves: Aggressive management of agitation and hyperthermia Management of cardiovascular complications Management of seizures or other neurological complications References: Goldstein RA, DesLauriers C, Burda A, Johnson-Arbor K. Cocaine: history, social implications, and toxicity: a review. Semin Diagn Pathol. 2009 Feb;26(1):10-7. doi: 10.1053/j.semdp.2008.12.001. PMID: 19292024.  Brody SL, Slovis CM, Wrenn KD. Cocaine-related medical problems: consecutive series of 233 patients. Am J Med 1990;88(4):325–31.   Ferreira S, Crumb WJ, Jr., Carlton CG, Clarkson CW. Effects of cocaine and its major metabolites on the HERG-encoded potassium channel. J Pharmacol Exp Ther 2001;299(1):220–6 Richards JR, Garber D, Laurin EG, Albertson TE, Derlet RW, Amsterdam EA, et al. Treatment of cocaine cardiovascular toxicity: a systematic review. Clin Toxicol (Phila) 2016;54(5):345–64. Wood DM, Dargan PI, Hoffman RS. Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction. Clin Toxicol (Phila) 2009;47(1):14–23