Weniger Chemo bei Akuter Leukämie? DNA-Methylierung als Target!

In no other type of cancer is the link to chemotherapy as clear and irrefutable as in acute myeloid leukemia (AML) – which makes the study data that surfaced last December all the more remarkable... In this video, we'll examine whether, and if so, how, the therapy for myelodysplastic syndromes (MDS) can also be applied to "fit" AML patients – and we'll also introduce the concept of epigenetics using DNA methylation as an example – more on that soon! Disclaimer: The various MDS therapies and AML therapies, including stem cell transplantation, are very complex – more information is available upon request! 00:00 Less Chemotherapy for Acute Leukemia? DNA Methylation as a Target! 01:31 Introduction [SKIP INTRO] 02:16 Chemotherapy - established in hematology... 03:44 ...with potential for expansion in oncology 04:47 AML "fit": 7+3, S-HAM 07:31 MDS: Azacitidine, Decitabine 09:39 AML "unfit": Azacitidine + Venetoclax 11:17 Head-to-Head: The PARADIGM Study 15:03 Criticism of the Study 17:07 OUTRO _________________________________ Music: "Crema" by Timothy Infinite (Epidemic Sound) Thumbnail: ChatGPT