EASD 2025

For over three decades, the Yale University scientist, Gerald I. Shulman has pursued a single mystery: why the body sometimes stops responding to its own insulin. His answer changed the field - as this video reveals. Shulman discovered that fat stored in the wrong places - inside muscle and liver cells - can jam the body’s insulin signalling system, triggering insulin resistance and type 2 diabetes. He showed how lifestyle changes and new experimental drugs can remove this hidden fat, restore insulin sensitivity, and normalise blood glucose levels - often within weeks.