Ask Your Doctor About This First: The Kidney Medication That Works 39% Better

SGLT2 vs GLP-1 for kidney disease: which medication should you ask about first? In this live AMA, I break down DAPA-CKD (39% reduction, stopped early), the FLOW trial (24% kidney event reduction), and new sleep regularity data showing 48% lower mortality in consistent sleepers. Watch to learn the real trial numbers, a 5-step sleep prescription backed by data from over 60,000 adults, and the exact questions to bring to your next doctor visit. ━━━━━━━━━━━━ TIMESTAMPS: 00:00 Introduction 00:45 Why I Care About This Topic 01:30 Subscribe CTA + Disclaimer 02:15 Tonight's Three Big Ideas 03:30 Live Chat Engagement 05:30 We're Still Missing Early CKD (Karolinska Study: 1.1 Million Adults) 13:00 SGLT2 Inhibitors: DAPA-CKD Trial (39% Reduction, Stopped Early) 14:00 GLP-1s: FLOW Trial (24% Kidney Event Reduction, NNT 39) 20:00 SGLT2 vs GLP-1 Head-to-Head (JAMA Internal Medicine Data) 22:00 Obesity and CKD: KDIGO 2026 Update 31:00 GLP-1s Without Diabetes (SELECT Trial Data) 39:00 GLP-1s, Muscle Loss, and Frailty 46:00 Sleep as a Longevity Drug (48% Mortality Reduction with Regular Sleep) 53:00 Your 4-Point Doctor Visit Checklist 56:00 Live Q&A ━━━━━━━━━━━━ IN THIS VIDEO: DAPA-CKD: Dapagliflozin cut kidney failure risk by 39% and may delay dialysis by 6.6 years. The trial was stopped early for benefit. FLOW Trial: Semaglutide reduced major kidney events by 24%, cardiovascular events by 18%, and all-cause death by 20% in patients with type 2 diabetes and CKD. A study of 1.1 million adults found that a "normal" eGFR of 80 in a 55-year-old woman actually represents the 10th percentile, with a 3x higher dialysis risk. 75% of at-risk patients never got a urine albumin test. Sleep regularity is a stronger predictor of death than sleep duration. The most regular sleepers had up to 48% lower all-cause mortality. Just 2 weeks of consistent bedtime lowered blood pressure by 4-5 mmHg. ━━━━━━━━━━━━ RESEARCH CITED: 1. DAPA-CKD Trial (Heerspink et al., NEJM 2020) — 39% reduction in primary kidney outcome, NNT 19 2. FLOW Trial (Perkovic et al., NEJM 2024) — 24% reduction in major kidney events, NNT 39 3. SGLT2 vs GLP-1 Comparative Effectiveness (Jensen et al., JAMA Intern Med 2026) 4. Karolinska eGFR Percentile Study (Yang et al., Kidney International 2026) 5. Sleep and Life Expectancy (McAuliffe et al., SLEEP Advances 2025) 6. Sleep Regularity and Mortality (Windred et al., SLEEP 2024) — 48% lower mortality in regular sleepers 7. Sleep Regularity and Cardiovascular Events (Chaput et al., J Epidemiol Community Health 2025) — 72,269 UK adults 8. Bedtime Regularization and Blood Pressure (Thosar et al., SLEEP Advances 2025) — 4-5 mmHg BP drop in 2 weeks 9. Sleep Hygiene Strategies in CKD (Systematic Review, Kidney International 2025) — Exercise and relaxation most effective 10. Sleep Regularity Systematic Review (Kalkanis et al., Sleep Medicine Reviews 2025) — 59 studies, 20-88% higher mortality in irregular sleepers 11. KDIGO 2026 Obesity in CKD Report (Furth et al., Kidney International 2025) 12. Semaglutide and Alcohol Use Disorder (Wang et al., Nature Communications 2024) ━━━━━━━━━━━━ SUPPORT THIS CHANNEL Your support keeps these videos free for everyone.    / @seanhashmimd   Tap JOIN next to Subscribe. Thank you. ━━━━━━━━━━━━ SUBSCRIBE for weekly health videos:    / @seanhashmimd   ━━━━━━━━━━━━ Questions? Drop them below. ━━━━━━━━━━━━ CONNECT: Instagram:   / seanhashmimd   Newsletter: https://www.selfprinciple.org/newsletter Website: https://www.selfprinciple.org ━━━━━━━━━━━━ MEDICAL DISCLAIMER: This video is for educational purposes only and is not medical advice, diagnosis, or treatment. Always consult your healthcare provider before making changes to your health routine. Viewing this content does not establish a doctor-patient relationship. The views and opinions expressed are Dr. Hashmi's personal professional opinions and do not represent the views of any employer, healthcare institution, or affiliated organization. #ChronicKidneyDisease #SGLT2Inhibitors #GLP1 #SleepHealth #EvidenceBasedMedicine #HealthOptimization #PreventiveMedicine #SeanHashmiMD