All you need to know about EBM: A founder's guide to evidence, guidelines & getting back to the core

What was medicine like before evidence-based medicine (EBM)? Gordon Guyatt, MD, the pioneer who coined the term EBM, reveals how a revolutionary movement transformed clinical practice from reliance on expert opinion and intuition to systematic evaluation of research evidence. Dr Guyatt candidly discusses both the triumphs and limitations of the EBM’s evolution while emphasizing a crucial insight that challenges the “cookbook medicine” critique: most clinical decisions require personalized shared decision-making between doctors and patients, because evidence alone cannot account for individual values and preferences. Hosted by Roman Jaeschke, MD, MSc. 00:00 The origins and foundations of EBM: moving beyond traditional clinical decision-making 02:54 The structured approach to clinical questions: understanding PICO framework and literature search methods 04:57 Evidence evaluation and the importance of trade-offs in clinical decision-making 07:05 The evolution from individual evidence appraisal to systematic evidence synthesis and guidelines 10:35 Strong vs conditional recommendations: avoiding “cookbook medicine” while maintaining evidence-based standards 14:15 Managing clinical uncertainty: lessons from hormone replacement therapy and shared decision-making 17:10 Patient communication in evidence-based practice: real-world examples of uncertainty and value-based decisions 19:51 The development and evolution of GRADE: from GOBSAT to structured evidence assessment 24:13 GRADE's global impact 26:20 Core GRADE: simplifying complex methodology for practical implementation The McMaster Perspective interview series is a collection of in-depth conversations that brings together the world’s leading medical experts and McMaster University’s renowned EBM approach. ▶️ YouTube playlist:    • McMaster Perspective   📌 See more at https://www.mcmastertextbook.one #McMasterPerspective #EBM #MedEd