Top 10 Multiple Myeloma Breakthroughs from ASH 2025 | CAR-T & Bispecific Antibodies Explained

Over a thousand multiple myeloma studies were unveiled at ASH 2025, but which ones truly matter for people living with myeloma today? In this video, IMF Chief Medical Officer Dr. Joseph Mikhael highlights the 10 most impactful myeloma research breakthroughs, including advances in CAR T-cell therapy, bispecific antibodies, and treatments for high-risk and extramedullary disease. If you or a loved one is navigating myeloma, this is a must-watch summary of what’s changing now and what’s coming next. #imfash25 #ASH25 #ASKTHEIMF Topics Covered in this Video: 0:00 - Introduction 1:35 - Faster CAR T-cell manufacturing delivered "in vivo" within the body 2:47 - CAR T-cell therapy results in early vs late relapse 3:34 - Managing rare CAR T side effects 4:29 - New CAR T strategies in frontline myeloma 5:11 - Next-generation CAR T without delayed neurotoxicity 5:50 - Curious about joining a clinical trial? Here's how 6:49 - Record-setting bispecific antibody combinations 7:35 - Using bispecifics earlier in treatment 8:05 - MRD-guided treatment escalation 9:32 - New hope for extramedullary myeloma 10:08 - Learn more at myeloma.org With all this groundbreaking new research, you may wonder, “how can I be part of the clinical trials that are moving the needle toward the cures for myeloma?” The IMF makes searching for clinical trials simple with our clinical trial matching engine. Visit www.myeloma.org/sparkcures to find a trial today. Have a question that needs more personalized support? Call us! We’re here for you. The IMF’s InfoLine is available to answer your myeloma-related questions and concerns. Call us at 1-818-487-7455, email us at [email protected], or schedule your call at a time that works best for you at: https://www.myeloma.org/infoline. _______________ Improving Lives | Finding the Cure Founded in 1990, the International Myeloma Foundation (IMF) is the first and largest organization focusing specifically on multiple myeloma. The IMF’s reach extends to more than 525,000 members in 140 countries worldwide. The IMF is dedicated to improving the quality of lives of myeloma patients while working toward prevention and a cure through our four founding principles: Research, Education, Support, and Advocacy. Subscribe to our channel:    / imfmyeloma   Visit our website at: https://www.myeloma.org Find us online: Facebook: @myeloma |   / myeloma   X/Twitter: @IMFMyeloma |   / imfmyeloma   Instagram: @imfmyeloma |   / imfmyeloma   LinkedIn:   / international-myeloma-foundation   Support the IMF | Donate Now! https://fundraise.myeloma.org/give/52... Category Nonprofits & Activism License Standard YouTube License The International Myeloma Foundation is committed to accessibility for all. That’s why all English-language videos uploaded to our YouTube channel feature human-transcribed closed captioning. This ensures more accurate captions for viewers who are Deaf or hard of hearing and improves the quality of automatic translations into other languages for our global audience.