Aula 2 - Fases de Ação Efeitos de Grupos Propriedades FQ (Parte 2)

Lesson 2 – Part 2 Physicochemical Properties: Assoc. Prof. Roberto Parise Filho – FCF/USP In this second part of Lesson 2 of Medicinal Pharmaceutical Chemistry, we delve deeper into the main physicochemical descriptors that determine the behavior of drugs in the body. We discuss how properties such as lipophilicity (LogP) and ionization constant (pKa) influence absorption, distribution, permeability of biological membranes, and pharmacokinetic profile. 🔬 Topics covered: • Partition coefficient (LogP) • Relationship between lipophilicity and membrane crossing • Ionization constant (pKa) • Henderson–Hasselbalch equation • Degree of ionization in different biological compartments • Influence of pH (gastric, intestinal, and plasma) • Applied examples with β-blockers and anti-inflammatory drugs 🎯 Lesson objective: To understand how physicochemical properties directly impact pharmacokinetics and are fundamental in the rational design of new drugs. 📍 Subject: Medicinal Pharmaceutical Chemistry 🏛 Faculty of Pharmaceutical Sciences – USP 🔬 LAPESSB – Laboratory for the Planning and Synthesis of Bioactive Substances 📩 Contact: [email protected]