The zoonotic potential of chronic wasting disease | OCS Science Seminar

Presenter: Dr. Sabine Gilch, University of Calgary Chronic wasting disease (CWD) is a fatal and transmissible neurodegenerative disease that affects wild and farmed cervids. It is spreading across North America at increasing rates, with cases detected in 31 US states and 4 Canadian provinces. CWD is, similar to BSE (“mad cow disease”) or human diseases like Creutzfeldt-Jakob disease, caused by prions, unconventional infectious agents that only consist of protein. BSE was transmitted to humans, and since infectious prions in CWD-affected cervids are detectable in many tissues including skeletal muscle and antler velvet, there are valid concerns about the ability of CWD prions to infect humans. This presentation will summarize the current knowledge about CWD zoonotic potential, and discuss our recently published study demonstrating that CWD prions from deer can cause an atypical prion disease with fecal shedding in ‘humanized’ transgenic mice. --- The Science Seminar Series is a venue for sharing information relevant to Alberta’s environmental monitoring and science programs in understandable and accessible ways. The Science Seminars are hosted by the Government of Alberta's Office of the Chief Scientist (OCS). https://www.alberta.ca/albertas-envir... The Government of Alberta respectfully acknowledges that our Edmonton offices are located on the traditional lands and gathering place for Treaty 6 Nations and the diverse Indigenous peoples including the Cree, Blackfoot, Nakota Sioux, Iroquois, Dene, Ojibway/Saulteaux/Anishinaabe, and the Metis and Inuit peoples, and many others whose histories, languages, and cultures continue to influence our vibrant communities today.