Introducing Roche Sequencing by Expansion (SBX) Technology

Welcome to a new space in NGS with sequencing by expansion (SBX). SBX technology utilizes a proprietary biochemical conversion process to expand and encode the sequence of a DNA template into a surrogate polymer, called an Xpandomer. These molecules are then passed through a high-density complementary metal oxide semiconductor (CMOS)-based sensor module with millions of biological pores, enabling accurate sequencing of hundreds of millions of bases per second. This novel approach aims to deliver speed, flexibility, and scalability so you can expand your sequencing capabilities beyond today’s limits. 00:00 Overcoming sequencing limitations with Xpandomers 00:34 X-NTP structure 01:20 The translocation control element 01:31 X-NTP incorporation 01:56 Threading of Xpandomer through pore 02:35 Measurement of Xpandomer reporters in a highly-parallel manner 02:59 A new paradigm for NGS technology Subscribe to our YouTube channel now: https://www.youtube.com/user/roche?su... Get in touch with us: https://www.roche.com/   / roche     / roche     / roche     / roche   Roche has been committed to improving lives since the company was founded in 1896 in Basel, Switzerland. Today, Roche creates innovative medicines and diagnostic tests that help millions of patients globally. Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and neuroscience. For more information and insights visit: https://www.roche.com/