Where to Inject for MAXIMUM GLP-1 Weight Loss | What the Data Shows

#GLP1 #Ozempic #Zepbound #WeightLossJourney #ObesityMedicine Injecting your GLP-1 in the same spot every week and wondering if another site would work better? I break down the actual Eli Lilly pharmacokinetic study comparing abdomen, thigh, and upper arm injections for tirzepatide (Mounjaro/Zepbound) — what the data really shows about absorption, side effects, and appetite suppression, and where the study's small sample size means the "abdomen wins" headline deserves a second look. By the end, you'll know exactly how much injection site affects your results — and where to actually focus if you want long-term success on GLP-1 therapy. Learn the full framework I use with my own patients — nutrition, training, and troubleshooting your treatment — inside my GLP-1 Masterclass: https://drmohammedpaika.com Timestamps 0:00 Cold Open 0:57 Meet Dr. Paika 1:38 The 3 Questions This Video Answers 2:50 How GLP-1 & GIP Actually Work 4:57 The 3 FDA-Approved Injection Sites 6:18 Why This Study Matters 7:58 Inside the Study: Design & Methodology 9:06 The Half-Life Detour (Why 35 Days) 10:27 Finding #1: Total Drug Absorbed (AUC) 12:55 Finding #2: Peak Concentration (Cmax) 14:16 Finding #3: Side Effects & Appetite Suppression 15:50 Patient Story: 61 Lbs Down 17:20 Does Rotating Injection Sites Matter? 19:44 My Actual Recommendation 21:09 Where to Go From Here 📩 Subscribe to our newsletter for weekly insights on GLP-1 science, metabolic health, longevity, and healthy recipes — plus a free GLP-1 Diet Cookbook when you subscribe: https://www.drmohammedpaika.com/newsl... 📘 GLP-1 Masterclass Book (PDF): https://www.drmohammedpaika.com/glp1e... 🎓 Complete GLP-1 Weight Loss Masterclass: https://www.drmohammedpaika.com 👨‍⚕️ ABOUT DR. MOHAMMED K. PAIKA Board-Certified in Internal Medicine and Obesity Medicine Certified Personal Trainer & Nutrition Coach Helping people understand metabolism, hormones, and sustainable health through evidence-based medicine. 👍 Like 💬 Comment 📌 Share 🔔 Subscribe for more honest conversations about obesity, metabolism, hormones, and real-world health solutions References: 1. Urva S, et al. Injection site does not affect the pharmacokinetics of tirzepatide. Clin Pharmacol Drug Dev. 2021. — https://clinicaltrials.gov/study/NCT0... 2. Mounjaro (tirzepatide) Prescribing Information. Eli Lilly and Company, FDA-approved labeling. — https://www.accessdata.fda.gov/drugsa... 3. Zepbound (tirzepatide) Prescribing Information. Eli Lilly and Company, FDA-approved labeling. — https://www.accessdata.fda.gov/drugsa... 4. Jastreboff AM, et al. Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1). N Engl J Med. 2022;387(3):205-216. — https://www.nejm.org/doi/full/10.1056... 5. FDA Clinical Pharmacology Review, NDA 215866 (tirzepatide) — half-life and elimination data. — https://www.accessdata.fda.gov/drugsa... ⚕️ MEDICAL & EDUCATIONAL DISCLAIMER This channel and its content are provided by Dr. Mohammed K. Paika, MD for general educational and informational purposes only. The information presented is not intended as medical advice and does not replace consultation with your personal physician or qualified healthcare professional. Viewing this content does not create a doctor-patient relationship between you and Dr. Paika. Health, nutrition, exercise, and medication topics discussed on this channel may not be appropriate for all individuals. Always consult your own healthcare provider before starting or changing any medication, diet, exercise program, or weight-loss plan, including GLP-1 therapies such as Wegovy, Ozempic, Zepbound, Mounjaro, or similar medications. Exercise and lifestyle changes carry inherent risks. By choosing to follow any information from this channel, you accept full responsibility for your health decisions and outcomes. Dr. Paika and affiliated entities disclaim any liability for injuries, adverse effects, or damages resulting from use or application of information presented in this content.