Advancing Immunotherapy Testing with Functional Antigen Specific T Cells

Immunotherapy has transformed cancer treatment, but persistent challenges, such as T cell exhaustion, limited persistence, and variability in response, continue to impact therapeutic success. Antigen-specific T cells, central to adaptive immunity, offer a powerful platform for evaluating and optimising immunotherapies. This webinar provides a concise overview of strategies for generating TCR-T and endogenous antigen-specific T cells, comparing these approaches with CAR-T and other modalities, and addressing key hurdles in specificity, durability, and exhaustion. We highlight RoukenBio's innovative capability to produce scalable banks of functional antigen-specific T cells, implement rescue strategies for exhausted phenotypes, and expand into NK cells, γδ T cells, and CAR-T platforms. A case study will demonstrate how TCR-T cells can assess immune modulators through measurable endpoints such as IFN-γ secretion and CD137 activation, delivering actionable insights for drug development, in collaboration with BioIVT, whose robust immune cell solutions form the foundational starting material for these advancements, with a commitment to Quality and Operational Excellence, ensuring researchers receive highly reliable and ethically sourced PBMCs and purified cell subsets. Learn about BioIVT’s Donor Management capabilities, featuring a diverse and well-characterized donor base (including HLA-typed donors), along with custom processing and collection processing and collection services optimized for client demand. Watch now to explore next-generation solutions that enhance immunotherapy evaluation and accelerate translational research. Key concepts and learning objectives in this webinar include: Understand the role of antigen-specific T cells in adaptive immunity and their application in immunotherapy testing. Compare TCR-T and endogenous T cell generation strategies, including challenges and rescue approaches for exhaustion. Learn how RoukenBio and BioIVT capabilities enable scalable, flexible platforms for translational research and collaboration for researchers across auto-immunity, immuno-oncology and complex cell therapy development. Download the slides: https://bioivt.com/educational-conten... Additional scientific resources and webinars: RoukenBio: https://rouken.bio/scientific-resources BioIVT: https://bioivt.com/resources/educatio... Questions, comments and requests: RoukenBio: https://rouken.bio/contact-us BioIVT: https://bioivt.com/about/contact-us Product and service information: RoukenBio: https://rouken.bio BioIVT: https://bioivt.com Receive upcoming webinar and new resource notifications: RoukenBio (via LinkedIn):   / scientific-newsletter-7175892612531269633   BioIVT (via email): https://bioivt.com/resources/newslett... BioIVT (via LinkedIn):   / bioivt-scientific-resources-73161704004328...   Presenters: Emilio Cosimo, PhD, Scientific Director of Innovation, RoukenBio Kevin King, Senior Scientific Advisor, CGT at BioIVT