Understanding ALS Through Genetics Presented by Dr. Frederick "Eric" Arnold

Although only approximately 10% of ALS cases are classified as “familial,” growing evidence suggests that genetics plays an important role in the remaining 90% of “sporadic” ALS cases, which occur in individuals without a family history of disease. Rather than being driven by a single inherited mutation, sporadic ALS likely arises from the combined effects of multiple genetic variants, each contributing modestly to disease risk and acting in parallel with environmental and age-related risk factors. In this talk, I will introduce the methods used to identify new genetic risk factors for ALS and discuss how studying ALS genetics can inform our understanding of the key biological pathways that influence motor neuron survival. Importantly, with new (and improved) gene therapy approaches now becoming available, defining genetic contributors to sporadic ALS may uncover therapeutic targets relevant to the vast majority of ALS patients. -- Our mission is to unite and empower the ALS community through a collaborative approach to fostering bold research initiatives, advancing national and state advocacy, and providing comprehensive care and support to individuals and families affected by ALS. ALS United Mid-Atlantic serves people with ALS in Pennsylvania, New Jersey, and Delaware. To learn more about our programs and research and how to support our initiatives, visit www.alsmidatlantic.org