Episode 406: Drug Resistance Biomarkers and Their Impact on Cancer Treatment Choices

"Our goal of precision oncology has been to shift to tailored therapies that can help to improve treatment efficacy and ultimately improve patient outcomes. Resistance biomarker testing can help the care team to detect these genomic changes that the tumor may have acquired during therapy that makes the cells resistant to therapy. This information can be extremely helpful when we're talking about making choices about second-line or subsequent-line therapy," ONS member Danielle Fournier, DNP, APRN, AGPCNP-BC, AOCNP®, advanced practice RN at the University of Texas MD Anderson Cancer Center in Houston, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about drug resistance biomarker testing. This podcast episode is sponsored by AstraZeneca. ONS is solely responsible for the criteria, objectives, content, quality, and scientific integrity of its programs and publications. Music Credit: "Fireflies and Stardust (http://www.incompetech.com/) " by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Episode Notes • This episode is not eligible for NCPD credit. • ONS Podcast™ episodes: • Episode 389: Biomarker Testing for Non-Small Cell Lung Cancer (https://www.ons.org/education-hub/onc...) • Episode 373: Biomarker Testing in Prostate Cancer (https://www.ons.org/education-hub/onc...) • Episode 169: How Biomarker Testing Drives the Use of Targeted Therapies (https://www.ons.org/education-hub/onc...) • ONS Voice articles: • Help Your Patients Understand Biomarker Resistance Testing (https://www.ons.org/publications-rese...) • Key Patient Education Points for Biomarker Resistance Testing (https://www.ons.org/publications-rese...) • Quick Quiz: How Much Do You Know About Drug Resistance in Cancer? (https://www.ons.org/publications-rese...) • Quick Quiz: How Much Do You Know About Somatic Biomarker Resistance Testing? (https://www.ons.org/publications-rese...) • When Targeted Therapy Stops Working, What's Next? Discover How Biomarker Resistance Testing Opens New Doors (https://www.ons.org/publications-rese...) • ONS Biomarker Database (https://www.ons.org/clinical-tools/bi...) • Clinical Journal of Oncology Nursing article: Tumor-Agnostic Therapies Reshaping Cancer Care (https://doi.org/10.1188/24.CJON.539-543) • ONS book: Understanding Genomic and Hereditary Cancer Risk: A Handbook for Oncology Nurses (https://www.ons.org/store/books/under...) • ONS course: Genomic Foundations for Precision Oncology (https://www.ons.org/store/courses/gen...) • ONS Genomics and Precision Oncology Learning Library (https://www.ons.org/genomics-and-prec...) • American Cancer Society Cancer Action Network: • Access to Biomarker Testing page (https://www.fightcancer.org/what-we-d...) • White paper: The Landscape of Biomarker Testing Coverage in the United States (https://www.fightcancer.org/sites/def...) • Find out which states are currently discussing biomarker testing bills and how you can advocate for them through ONS (https://www.votervoice.net/ONS/Home) . To discuss the information in this episode with other oncology nurses, visit the ONS Communities (http://communities.ons.org/) . To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library (https://www.ons.org/learning-librarie...) . To provide feedback or otherwise reach ONS about the podcast, email [email protected] (mailto:[email protected]?subject=Website%20feedback%20from:%20Oncology%20Drug%20Reference%20Sheet:%20Trilaciclib) . Highlights From This Episode "We know that biomarkers are playing an ever more important role in cancer care, and really, their use can range anywhere from helping us to confirm a give...