F. Fallarino - Beyond Antigen Presentation: Shaping Immune Reactivity or Tolerance through ...

Francesca Fallarino, Istituto Italiano di Tecnologia (IIT), Center for Genomic Science of IIT@SEMM, Milan, ITALY spaeks on "Beyond Antigen Presentation: Shaping Immune Reactivity or Tolerance through Vesicular and Metabolic Control by Dendritic Cells. Abstract Dendritic cells (DCs) are pivotal regulators of immune responses, orchestrating the balance between immune activation and tolerance. This talk will explore the multifaceted roles of DCs as central actors shaping the immunological landscape—modulating immune reactivity during inflammation and tumor progression, while also promoting tolerance in contexts such as self-antigen recognition. Emphasis will be placed on our recent discoveries revealing how DC subsets, their metabolism, and microenvironmental cues including extracellular vesicles converge to influence their functional fate. Understanding these mechanisms opens new avenues for targeted immunotherapies and strategies to induce immune tolerance.