ERC Advanced Grant 2019 Recipient Prof. Seth Grant - Interview by EURAXESS Australia & New Zealand

Australian Neuroscientist Prof. Seth Grant talks to EURAXESS Australia & New Zealand Regional Representative Nishant Shandilya about winning an ERC Advanced Grant. ********************* Follow us on: Facebook:   / euraxess.aus.nz   LinkedIn:   / euraxess-aus-nz   Sign up for free Membership: https://euraxess.ec.europa.eu/worldwi... ********************* For potential applicants: Researchers who would like to compete for an ERC Advanced Grant have from 14 May to 26 August 2020 to apply for the next round of funding. More information about the funding and applications: https://erc.europa.eu/funding/advance... ********************* Prof. Seth Grant directs world-leading research at the Centre for Clinical Brian Sciences, University of Edinburgh, UK. Over the last 25 years, his laboratory has made seminal contributions to understanding the roles played by synapses – the connections between each nerve cell – in learning, memory, and the mechanisms underlying innate and learned behaviours. This work has revealed how synapse dysfunction contributes to a wide range of developmental, neurodegenerative and psychiatric brain disorders of great social and economic importance, including schizophrenia, autism, depression, addiction and intellectual disability. These studies in humans and in genetic models of disease have encompassed all scales, from molecular proteomics and transcriptomics to whole-brain networks and animal behavior. In particular, Prof. Grant’s work has been fundamental in uncovering and then characterising the diversity of postsynaptic proteins and the dynamics of their assembly into complexes and supercomplexes in different neurons and regions of the brain, furthermore providing insight into synapse evolution and its role in the establishment of vertebrate behavioural complexity. Recently, Prof. Grant’s lab has pioneered synaptome mapping, a transformative technology that has produced the first single-synapse resolution maps of the whole mouse brain, uncovering unprecedented spatiotemporal synapse diversity and architecture. Synaptome mapping is not only revealing how the brain changes during normal development and ageing, but also has the potential to make a major contribution to uncovering the mechanisms and consequences of brain dysfunction, leveraging insight at unprecedented spatiotemporal resolution and scale into disease impacts on neuronal populations in the brain throughout the lifespan. Prof. Grant’s research has generated a wealth of freely available interdisciplinary datasets (proteomic, genetic, transcriptomic, electrophysiological, behavioural, synaptomic) and analysis tools for the neuroscience community. ********************* "Royalty Free Music from Bensound"'