ANCA-associated Vasculitis: Update Therapy 2023 - Prof. Dr. Alexandre Karras (Paris, France)

Professor Alexandre Karras discusses major changes in the treatment of ANCA-associated Vascutitis (AAV) since the publication of KDIGO guidelines on glomerulonephritis in 2021, and their reflection in the 2023 KDIGO AAV 2023 update. Professor Alexandre Kassas is nephrologist in the Hôpital Européen Georges-Pompidou in Paris, France; he has published numerous studies on the epidemiolgy and treatment of AAV. The interview was recorded on June 5nd, 2023. Moderators: Prof. Dr. Dominique Guerrot (Rouen, France), Prof. Dr. Marion Haubitz (Fulda, Germany), Priv.-Doz. Dr. Andreas Kronbichler (Innsbruck, Austria), and Prof. Dr. Gunnar Heine (Frankfurt, Germany). Articles discussed: Kidney Histopathology Can Predict Kidney Function in ANCA-Associated Vasculitides with Acute Kidney Injury Treated with Plasma Exchanges. Nezam D, Porcher R, Grolleau F, Morel P, Titeca-Beauport D, Faguer S, Karras A, Solignac J, Jourde-Chiche N, Maurier F, Sakhi H, El Karoui K, Mesbah R, Carron PL, Audard V, Ducloux D, Paule R, Augusto JF, Aniort J, Tiple A, Rafat C, Beaudreuil S, Puéchal X, Gobert P, Massy Z, Hanrotel C, Bally S, Martis N, Durel CA, Desbuissons G, Godmer P, Hummel A, Perrin F, Néel A, De Moreuil C, Goulenok T, Guerrot D, Grange S, Foucher A, Deroux A, Cordonnier C, Guilbeau-Frugier C, Modesto-Segonds A, Nochy D, Daniel L, Moktefi A, Rabant M, Guillevin L, Régent A, Terrier B; on behalf of the French Vasculitis Study Group. J Am Soc Nephrol. 2022 doi: 10.1681/ASN.2021060771 Proteinuria and hematuria after remission induction are associated with outcome in ANCA-associated vasculitis. Benichou N, Charles P, Terrier B, Jones RB, Hiemstra T, Mouthon L, Bajema I, Berden A, Thervet E, Guillevin L, Jayne D, Karras A; French Vasculitis Study Group (FVSG) and European Vasculitis Society (EUVAS) investigators. Kidney Int. 2023 doi: 10.1016/j.kint.2023.02.029 Combination treatment with rituximab, low-dose cyclophosphamide and plasma exchange for severe antineutrophil cytoplasmic antibody-associated vasculitis. Gulati K, Edwards H, Prendecki M, Cairns TD, Condon M, Galliford J, Griffith M, Levy JB, Tam FWK, Tanna A, Pusey CD, McAdoo SP. Kidney Int. 2021 doi: 10.1016/j.kint.2021.08.025 Score to assess the probability of relapse in granulomatosis with polyangiitis and microscopic polyangiitis. Samson M, Devilliers H, Thietart S, Charles P, Pagnoux C, Cohen P, Karras A, Mouthon L, Terrier B, Puéchal X, Guillevin L. RMD Open. 2023 doi: 10.1136/rmdopen-2022-002953 Patients of 75 years and over with ANCA-associated vasculitis have a lower relapse risk than younger patients: A multicentre cohort study. Thietart S, Beinse G, Smets P, Karras A, Philipponnet C, Augusto JF, El Karoui K, Mesbah R, Titeca-Beauport D, Hamidou M, Carron PL, Maurier F, Sacre K, Cohen P, Liozon E, Blanchard-Delaunay C, Kostianovsky A, Pagnoux C, Mouthon L, Guillevin L, Terrier B, Puéchal X; French Vasculitis Study Group. J Intern Med. 2022 doi: 10.1111/joim.13417 Treatment of systemic necrotizing vasculitides in patients aged sixty-five years or older: results of a multicenter, open-label, randomized controlled trial of corticosteroid and cyclophosphamide-based induction therapy. Pagnoux C, Quéméneur T, Ninet J, Diot E, Kyndt X, de Wazières B, Reny JL, Puéchal X, le Berruyer PY, Lidove O, Vanhille P, Godmer P, Fain O, Blockmans D, Bienvenu B, Rollot F, Aït el Ghaz-Poignant S, Mahr A, Cohen P, Mouthon L, Perrodeau E, Ravaud P, Guillevin L; French Vasculitis Study Group. Arthritis Rheumatol. 2015 doi: 10.1002/art.39011. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. Kidney Int. 2021 doi: 10.1016/j.kint.2021.05.021. Patients of 75 years and over with ANCA-associated vasculitis have a lower relapse risk than younger patients: A multicentre cohort study. Thietart S, Beinse G, Smets P, Karras A, Philipponnet C, Augusto JF, El Karoui K, Mesbah R, Titeca-Beauport D, Hamidou M, Carron PL, Maurier F, Sacre K, Cohen P, Liozon E, Blanchard-Delaunay C, Kostianovsky A, Pagnoux C, Mouthon L, Guillevin L, Terrier B, Puéchal X; French Vasculitis Study Group. J Intern Med. 2022 doi: 10.1111/joim.13417 Rituximab in anti-GBM disease: A retrospective study of 8 patients. Touzot M, Poisson J, Faguer S, Ribes D, Cohen P, Geffray L, Anguel N, François H, Karras A, Cacoub P, Durrbach A, Saadoun D. J Autoimmun. 2015 doi: 10.1016/j.jaut.2015.04.003