B cell activation and differentiation

B cell activation and differentiation -This lecture explains about the activation of B cell and the mechanism of B cell differentiation in Bone marrow and how B cell developed into the antibody making factories in immune system. It also explains the conversion of B cell into the plasma cells which is also known as the B cell maturation. B-Lymphocytes - derived from the bursa of Fabricius, or its equivalent, 1. ~ 10% of peripheral circulating lymphocytes 2. ~ 50% of splenic lymphocytes 3. ~ 75% of bone marrow lymphocytes differentiation occurs in the 3rd trimester in utero & the neonatal period all have membrane bound immunoglobulins, which attach via their Fc portion, a. IgM & IgD ~ 75% b. IgG ~ 24% c. IgA ~ 1% clonal expansion and differentiation to, 1. plasma cells - which produce specific antibody, and 2. memory cells - which readily produce plasma cells to repeat challenge, requires, i. Ig-Fab portion attaching specific antigen ii. antigen presented & pre-processed by macrophages iii. modulatory signals from other cells, especially T4-cells NB: plasma cells produce only one class of Ab which is specific for one antigen → theory of clonal specificity McFarlane Burnet Ab production may occur as above, with the co-operation of T-cells → the antigen is said to be thymus dependent antigen most antigens are of this class, and the Ab's produced include all classes thymus independent antibodies are exclusively of the IgM class For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-material... Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page-   / shomusbiology   Twitter -   / shomusbiology   SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/1136485849827... LinkedIn -   / suman-bhattacharjee-2a051661   Youtube-    / thefunsuman   Thank you for watching the video lecture on B cell activation and maturation.