GLP-1s and Fertility (What You Need to Know)

If you are on a GLP-1 and thinking about trying to conceive, this episode is a must watch. Dr. Spencer Nadolsky and Dr. Karl Nadolsky sit down with reproductive endocrinologist Dr. Lucky Sekhon, author of The Lucky Egg, to break down what people need to know about GLP-1 medications and fertility. They cover why many people with PCOS start ovulating again on GLP-1s, how insulin resistance impacts egg quality and implantation, when to see a fertility specialist, and why “AMH testing” is often misunderstood online. They also discuss the current safety guidance around GLP-1s in pregnancy, why recommendations often say to stop 2 months before trying, and what Dr. Lucky actually does in real IVF timelines to balance safety, anesthesia concerns, and avoiding backsliding. If you are trying on your own, doing IUI, or considering IVF, this conversation will help you understand the evidence, avoid misinformation, and make a plan with your doctor. Pick up Dr. Lucky’s book: https://www.amazon.com/Lucky-Egg-Unde... Follow Dr. Lucky: Instagram: @lucky.sekhon TikTok: @drluckyegg Subscribe for science-based episodes on weight loss, GLP-1s, and metabolic health. 00:00 – GLP-1s and fertility: why this episode matters 00:20 – Meet Dr. Lucky Sekhon and her book The Lucky Egg 02:23 – Dr. Lucky’s training path: REI explained 05:50 – Why she started posting online and wrote the book 08:07 – Biggest fertility myths and scams she sees 11:17 – What The Lucky Egg actually teaches 17:29 – Why fertility is so inefficient even when timed perfectly 19:11 – When to seek help (under 35, 35+, 40+) 20:31 – The fertility workup: eggs, tubes, uterus, sperm 22:25 – Male factor infertility: how common it really is 23:15 – Endometriosis and insulin resistance as “missed” causes 24:17 – AMH explained: what it can and cannot tell you 28:33 – PCOS and AMH: what high AMH can signal 31:03 – PCOS diagnosis basics and why it is often missed 33:11 – GLP-1s bringing periods back even without weight loss 34:05 – Why the guidance says stop GLP-1s before conception 35:28 – Insulin resistance: how it affects ovulation and egg quality 38:40 – Birth control and GLP-1s: what to know about oral pills 39:15 – A practical approach: GLP-1s, metformin, and TTC timelines 40:09 – Dr. Lucky’s IVF plan for GLP-1 users (anesthesia timing) 41:29 – Fear of regaining weight vs safety guidance in pregnancy 43:45 – Do GLP-1s improve IVF outcomes yet? What we know 44:00 – Weight, time, and the “optimize vs move forward” decision 48:03 – Egg quality drop-off and insulin resistance red flags 49:01 – Endometriosis: why it is complex and how it is treated 52:35 – Closing, where to find Dr. Lucky, and final message