Lecture On Endometrial Carcinoma: Pathology, Molecular Genetics & Staging | MBBS

In this detailed pathology lecture, we conduct a comprehensive review of Endometrial Carcinoma, covering its classification, molecular pathogenesis, and clinical prognosis. Designed for medical students and pathology trainees, this session breaks down the critical differences between Type 1 and Type 2 tumors, along with essential exam topics like Lynch Syndrome and the Arias-Stella reaction. Video Chapters: 00:00:00 - Introduction: Definition & Types of Endometrial Carcinoma 00:02:00 - Risk Factors: Type 1 (Endometrioid) vs. Type 2 (Serous) 00:03:20 - Pathogenesis & Precursor Lesions (Hyperplasia with/without Atypia) 00:05:03 - Genetics & Associations (Lynch Syndrome / HNPCC) 00:06:40 - Molecular Pathogenesis (PTEN Mutation, PI3K/AKT Pathway) 00:08:00 - Multistep Carcinogenesis & Microsatellite Instability 00:11:44 - Protective Factors & Clinical Features (Post-Menopausal Bleeding) 00:13:11 - Histopathology: Endometrioid vs. Serous vs. Clear Cell Carcinoma 00:17:23 - Carcinosarcoma & Tamoxifen Association 00:19:07 - Arias-Stella Reaction: Definition & Clinical Significance 00:21:34 - Spread, Metastasis & Prognostic Factors (Staging & Survival Rates) Key Learning Objectives: Differentiate between Type 1 (Estrogen-dependent) and Type 2 (Atrophy-associated) endometrial cancers. Understand the multi-step molecular pathogenesis involving PTEN and DNA mismatch repair (MMR) genes. Identify key histopathological features of Endometrioid, Serous, and Clear Cell variants. Master high-yield MCQ topics like Lynch Syndrome (HNPCC) and Tamoxifen-induced Carcinosarcoma. #EndometrialCarcinoma #Pathology #MBBS #MedicalEducation #UterineCancer #LynchSyndrome #Histopathology #Gynecology #SantiniketanMedicalCollege SANTINIKETAN MEDICAL COLLEGE & HOSPITAL Real Classroom Demonstration/Lecture On: PATHOLOGY by Dr. Utsab Das (MBBS Batch: (2024-25) Conducted on: 07-07-2026