Lemtrada (Alemtuzumab) for Multiple Sclerosis Explained by Neurologist

Timestamps: 00:59 Mechanism of Action 2:55 Treatment Logistics 5:23 Clinical Trial Results 7:37 Long Term Outcomes (TOPAZ Study) 12:21 Side Effects 16:37 Screening Tests 17:38 Safety Monitoring 18:13 Pregnancy/Breastfeeding I previously ranked Lemtrada as the 2nd most effective disease modifying therapy. This video explains how Lemtrada works and reviews some clinical trial results along with potential side effects. Selected Sources: Lemtrada product label: https://www.accessdata.fda.gov/drugsa... Pooled analysis of the CARE-MS, extension, and TOPAZ studies: https://journals.sagepub.com/doi/full... Immune reconstitution after Lemtrada: https://www.ncbi.nlm.nih.gov/pmc/arti... Changes in the immune system subsets after Lemtrada: https://jneuroinflammation.biomedcent... Brain atrophy after Lemtrada: https://www.ncbi.nlm.nih.gov/pmc/arti... Opportunistic infections with Lemtrada: https://pubmed.ncbi.nlm.nih.gov/29848... acquired haemophilia A as complications of alemtuzumab treatment for multiple sclerosis: https://pubmed.ncbi.nlm.nih.gov/33681... Comment or ask questions below! I would be happy to answer! Subscribe on YouTube for more videos every Wednesday! Make video requests in the comments section! My book "Resilience in the Face of Multiple Sclerosis" on Amazon: https://www.amazon.com/dp/B07WP7H5LK Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research. Follow me on twitter:   / brandon_beaber   Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link:    • Video   T he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.