#34 - Blut statt MRT? Neurofilamente (sNFL) als neuer Biomarker bei MS

Today's video is about sNFL as a new biomarker in multiple sclerosis. Neurofilament light chains (sNFL) can be measured in the blood and provide information about inflammatory activity in patients with MS. ``` Chapter Overview: 0:00 Introduction 0:56 MRI: Still the most important diagnostic method for monitoring MS progression 2:15 What exactly is a biomarker (including examples) 5:38 Neurofilaments (NFL) as a biomarker in MS: Basics 8:30 NFL levels are elevated in various diseases (e.g., Alzheimer's, trauma, ALS, MS) 11:20 Factors influencing NFL levels (age, kidney function, etc.) 12:09 NFL levels in multiple sclerosis 14:00 The z-score makes NFL levels more comparable (takes into account, for example, age and BMI) 15:09 Z-score: Patient examples 17:56 What does an elevated NFL level indicate in MS? (BRAIN Paper: Bittner et al.) 18:50 NFL levels decrease under effective immunotherapies (e.g., IFNβ-1a and ocrelizumab) 19:25 CONCLUSION: What role do NFL play in MS and how are they used for disease monitoring? 21:07 As of February 2025, NFL blood tests are not yet routine in neurological practices (...& outlook) NOTE: The content on this channel, including text, graphics, and images, is for general informational purposes only. It is NOT a substitute for professional medical advice, diagnosis, or treatment. Watching these videos does not replace medical consultation with a doctor/neurologist! ____ Further information about the channel and me can be found in the channel info.