New Treatments for IgA Nephropathy in 2025!

IgA nephropathy treatment has changed dramatically since 2021. Steroids are no longer your only option. In this video, I break down the complete treatment roadmap based on the 2021 KDIGO guidelines and the latest clinical trials. This is the same tiered approach I use with my IgA nephropathy patients every day. Watch to learn about foundation therapies everyone needs, targeted treatments for high-risk patients, and emerging drugs in the pipeline. ━━━━━━━━━━━━━━ TIMESTAMPS: 00:00 Introduction 01:21 How IgA Nephropathy Treatment Has Changed 02:51 Tier 1: Foundation Therapy (RAS Inhibitors) 04:30 Tier 1: SGLT2 Inhibitors 06:13 Tier 1: Blood Pressure Control 07:01 Tier 2: Who Needs Targeted Therapy? 07:33 Nefecon (Budesonide) Explained 09:29 Sparsentan (Filspari) Explained 11:14 Systemic Steroids: When They're Used 12:27 Pipeline: Complement Inhibitors & Future Treatments 14:02 How to Talk to Your Nephrologist 15:13 Your Action Plan ━━━━━━━━━━━━━━ IN THIS VIDEO: SGLT2 inhibitors reduce kidney failure risk by 30-40%, even without diabetes Sparsentan achieves 40% greater proteinuria reduction than ARBs alone Nefecon targets the gut where faulty IgA is produced, with fewer steroid side effects ━━━━━━━━━━━━━━ RESEARCH CITED: DAPA-CKD Trial (2020): SGLT2 inhibitors in CKD NefIgArd Trial (2023): Nefecon two-year outcomes PROTECT Trial (2023): Sparsentan vs. Irbesartan TESTING Trial (2021): Systemic steroids in IgA nephropathy ━━━━━━━━━━━━━━ FULL IgA NEPHROPATHY SERIES: Episode 1: What's REALLY Causing Blood in Your Urine After a Cold    • Blood in Your Urine? This Is What's Really...   Episode 2: What REALLY Happens When Your Immune System ATTACKS Your Kidneys    • What REALLY Happens When Your Immune Syste...   Episode 3: Lab Numbers That Predict Kidney Failure in IgA Nephropathy    • IgA Nephropathy: 3 Critical Labs Your Doct...   Episode 4: Best IgA Nephropathy Drug Options (this video) Episode 5: IgA Nephropathy Diet: The Eating Plan That Protects Kidneys    • IgA Nephropathy: The Kidney Diet Plan Doct...   Episode 6: 5-Step Action Plan to Protect Your Kidneys    • 5 Steps to Protect Your Kidneys Now   ━━━━━━━━━━━━━━ SUPPORT THIS CHANNEL Your support keeps these videos free for everyone.    / @seanhashmimd   Tap JOIN next to Subscribe. Thank you. ━━━━━━━━━━━━━━ SUBSCRIBE for weekly health videos:    / @seanhashmimd   ━━━━━━━━━━━━━━ Are you on an SGLT2 inhibitor? Was it hard to get insurance coverage? Drop your questions below. ━━━━━━━━━━━━━━ CONNECT: Instagram:   / seanhashmimd   Newsletter: https://www.selfprinciple.org/newsletter Website: https://www.selfprinciple.org ━━━━━━━━━━━━━━ MEDICAL DISCLAIMER: This video is for educational purposes only and is not medical advice, diagnosis, or treatment. Always consult your healthcare provider before making changes to your health routine. Viewing this content does not establish a doctor-patient relationship. The views and opinions expressed are Dr. Hashmi's personal professional opinions and do not represent the views of any employer, healthcare institution, or affiliated organization. #IgANephropathy #KidneyDisease #Nefecon #Sparsentan #SGLT2Inhibitors #EvidenceBasedMedicine #SeanHashmiMD