fatty liver disease (Clinical Essentials) - Dr. Kiran Peddi MRCP(UK), FRCP(London), CCT(Gastro)

📌𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash   📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash fatty liver disease (Clinical Essentials) - Dr. Kiran Peddi MRCP(UK), FRCP(London), CCT(Gastro) Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) NAFLD: non-alcohol-related accumulation of fat in the liver cells NASH: NAFLD with chronic inflammation and damage of liver cells Etiology ------------- Obesity and/or type 2 diabetes (metabolic syndrome) Pathology ---------------- Hepatocellular lipid accumulation, mostly macrovesicular Ballooning degeneration and necrosis Inflammatory infiltrates, with scattered lymphocytes, neutrophils, and Kupffer cells Pathophysiology ↑ Insulin resistance ↑ Triglyceride synthesis ↑ Hepatic uptake of fatty acids Clinical presentation ---------------------------------- Often asymptomatic Hepatomegaly May progress to cirrhosis Diagnostics -------------------- ↑ Transaminases (AST/ALT ratio greater than 1) The reversal of the AST/ALT ratio to values greater than 1 may indicate progression to cirrhosis. Rule out other causes of chronic hepatitis (e.g., heavy alcohol use, hepatitis B, hepatitis C, Wilson disease, autoimmune hepatitis, hemochromatosis, α1-antitrypsin deficiency) Therapy -------------- Weight loss, optimization of diabetic treatment Complications: cirrhosis, hepatocellular carcinoma #fattyliverdisease #fattyliver #fattylivercauses #fattylivertreatment #fattyliverdiagnosis #fattylivertreatment #fattyliversymptoms #fattyliveretiology #whatisfattyliver