Clindamycin | Erythromycin | Chloramphenicol | MOA & Clinical Correlations🩺

Clindamycin | Erythromycin | Chloramphenicol | MOA & Clinical Correlations🩺 Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $59 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/ --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 1000+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ 00:00:00 Introduction and overview of lecture 00:01:29 Overview of similarities between Clindamycin, Macrolide and chloramphenicol 00:02:17 Clindamycin, macrolide (Erythromycin) and chloramphenicol work as protein synthesis inhibitors 00:02:29 MOA of clindamycin, macrolide (Erythromycin) and chloramphenicol on Bacterial Ribosomes 00:02:44 MOA of clindamycin, macrolide (Erythromycin) and chloramphenicol on larger 50s ribosomal subunit 00:03:28 Action of clindamycin , macrolide (Erythromycin) and Chloramphenicol on 23s Ribosomal RNA 00:05:55 Summary of above 4 similarities in the MOA of Clindamycin , Macrolide (Erythromycin) and Chloramphenicol 00:06:27 MOA of Clindamycin, Macrolide (Erythromycin) and Chloramphenicol on Ribozyme 00:07:01 What is Peptidyl Transferase? 00:07:57 Summary of all above similarities between Clindamycin, Macrolide (Erythromycin) and Chloramphenicol 00:09:26 Detailed explanation on the functions of Peptidyl Transferase 00:22:08 Transpeptidation and Ribosomal Translocation 00:22:57 Peptide chain elongation 00:26:31 How Clindamycin, Macrolide (Erythromycin) and chloramphenicol inhibit the protein synthesis by inhibiting the chain elongation process? 00:28:19 Summary of similarities between Clindamycin, Macrolide (Erythromycin) and Chloramphenicol 00:31:46 MOA; Clindamycin 00:39:56 MOA; Clindamycin as bacteriostatic and bactericidal 00:52:14 Summary of MOA of Clindamycin 00:53:32 MOA; Macrolides (Erythromycin) 00:59:18 MOA; Chloramphenicol binding site. 01:00:55 MOA; Comparison of binding site of clindamycin vs macrolide vs chloramphenicol. 01:01:30 MOA; Chloramphenicol. 01:04:00 Chloramphenicol; Adverse effects. 01:06:55 Why clindamycin and macrolide (Erythromycin) don’t produce gray baby syndrome? 01:15:35 Clinical co-relation; Competitive Inhibition; Why clindamycin and erythromycin are not used together for a treatment of any infection? 01:18:40 Summary of role of clindamycin in TSS. 01:19:30 Clinical co-relation; Cross resistance. 01:20:05 Mechanism of resistance involving the changes at binding site, 23s rRNA. 01:20:30 Mechanism#1; Mutant ribosomal protein. 01:22:00 Mechanism#2; Mutation of adenine group at target site, 23s rRNA. 01:22:55 Mechanism#3; Methylation of adenine group at target site, 23s rRNA. 01:25:50 Clinical co-relation; Cross resistance because of erm genes. 01:31:25 Clinical co-relation; post-antibiotic effect in relation to clindamycin, erythromycin 01:38:26 Secondary effect#1; Reduced quantity of proteins 01:38:32 Secondary effect#2; Distorted proteins. 01:38:45 Bacteriostatic action/ Bactericidal action 01:39:28 Surface bacterial proteins altered; Decrease adherence of bacteria. 01:42:40 Excellent choice for abscesses produced by the susceptible bacteria. 01:43:05 Penetration of drug; Bones. 01:43:25 Penetration of drug; Can’t cross BBB. 01:43:45 Summary of all effects produced by clindamycin. 01:44:45 Black box warning for Clindamycin. 01:45:35 Pathogenesis of Pseudomembranous colitis. 01:47:25 Risk factors for Pseudomembranous colitis. 01:47:55 Directions to be given to the patient while prescribing clindamycin. 01:48:20 Treatment for C. diff colitis. 01:49:40 Summary of Black box warning for Clindamycin. --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to the perks: Sign up now on our website at https://members.drnajeeblectures.com/ Follow us on Facebook:-   / drnajeeb   Follow us on Instagram:-   / drnajeeblectures