💊 Antipsychotic Drugs (Part - 3) Mechanism Of Action | CNS Pharmacology | USMLE Step 1

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash   📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash 💊 Antipsychotic Drugs Part 3 – MOA | CNS Pharmacology | USMLE Step 1 Welcome to Part 3 of the high-yield series on Antipsychotic Drugs, where we dive into the classification, mechanisms of action, and key clinical differences between typical (first-generation) and atypical (second-generation) antipsychotics — a core topic in CNS pharmacology for the USMLE Step 1 exam. If Part 1 explained the “why” behind treating psychosis, this video explains the “how” — with a detailed focus on drug targets, dopaminergic pathways, and receptor selectivity. 🧠💊 We begin with the first-generation antipsychotics (FGAs), which are D2 receptor antagonists. These are divided into: – High-potency agents (e.g., haloperidol, fluphenazine): strong D2 blockade, higher risk of extrapyramidal symptoms (EPS) – Low-potency agents (e.g., chlorpromazine, thioridazine): more anticholinergic, antihistaminic, and α1-blocking effects, but less EPS Then we transition into the second-generation antipsychotics (SGAs), or atypical agents (e.g., risperidone, olanzapine, quetiapine, clozapine, aripiprazole), which block both D2 and 5-HT2A receptors. These drugs are better at treating negative symptoms and have a lower risk of EPS, but come with their own side effects like metabolic syndrome, weight gain, and diabetes. This video also explains: – Why clozapine is reserved for treatment-resistant schizophrenia (and why you must monitor CBC for agranulocytosis) – Which agents are safest in Parkinson’s disease psychosis – How aripiprazole’s partial D2 agonism reduces side effects – Why haloperidol is commonly used in acute agitation and delirium – High-yield comparisons between FGAs vs SGAs on Step 1 By the end of this lecture, you’ll be confident in classifying antipsychotics, predicting side effects based on potency and receptor profile, and choosing the right agent for different clinical scenarios — all critical skills for excelling in USMLE Step 1 and beyond. #AntipsychoticDrugs #TypicalVsAtypical #CNSPharmacology #USMLEStep1 #FirstGenerationAntipsychotics #SecondGenerationAntipsychotics #SchizophreniaDrugs #Haloperidol #Risperidone #Clozapine #Agranulocytosis #EPS #PharmacologyReview #DrGBhanuPrakash #WhiteboardMedicine #NBMEReview #Step1Prep #USMLEBuzzwords #Psychopharmacology #HighYieldNeuro #USMLE2025