John C. Reilly was "despairing" at the state of the world. How he found a way out.

From "Step Brothers" to “Chicago,” John C. Reilly imbues every one of his roles with humor, empathy, and heart. In his latest project, a vaudeville stage show called "Mister Romantic," he searches for connection in a disconnected time. He talked to Rachel about his independent childhood on the south side of Chicago, and being open to endless possibilities. CHAPTERS: 00:00 Introduction 1:10 Being a middle kid and John’s discovery of theater as a child. Appreciation of American musical. 6:17 Experiencing beauty in art class as a kid. Gratitude toward the teachers that knew how to support him. 9:29 Mining wild childhood experiences for “Step Brothers.” Running off without supervision as kid. 13:33 "Mister Romantic" and finding connection through music. Feeling alarmed about lack of empathy in our culture and trying to address it. 22:28 Feelings of envy early in career and realization of how to move past. 26:26 Being highly empathetic. Not being as funny as Will Ferrell when swearing. 29:35 Rachel wishes she could be a good house host. John wishes he was more organized. 34:51 John likes to keep all possibilities open. 36:16 Beliefs about life after death. John’s story about having a dream about his Dad the night his Dad died. 41:25 Fighting despair through connection 44:00 John’s Memory Time Machine MORE WILD CARD EPISODES    • Wild Card with Rachel Martin   WHAT IS “WILD CARD?” Life’s too short for small talk. NPR's Rachel Martin gets right to the questions that matter most. Once a week, famous guests pull questions from a deck of cards and open up about the kind of stuff we all think about but rarely say out loud. Actors, authors and thinkers are prompted to talk about everything from their insecurities and dreams to grief and God. Named one of The New York Times’ 10 best podcasts of 2024, Wild Card stands out among celebrity interview podcasts. When modern life feels chaotic or overwhelming, listen to Wild Card for a joyful, grounding reminder of our shared humanity. You can reach out to us at [email protected]. We love it when you do. The NPR shows you love are possible thanks to your support. Donate today: https://www.npr.org/donations/support

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Maya Hawke on the magic and witchiness of her parents and her childhood

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Harrison Ford: an honest (and hilarious) interview about rejecting advice and finding his own path

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The Zen Acting of The Big Lebowski | Acting Breakdown

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Conan O’Brien Delivers the Commencement Address | Harvard Commencement 2026

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The Iran War & Our Energy Future | The Weekly Show with Jon Stewart

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John Kiriakou | This Past Weekend w/ Theo Von #661

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Emily Blunt Is Up to the Challenge While Eating Spicy Wings | Hot Ones

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S13 E13: Freedom 250, Trump’s Pardons & Ghana Posters: 5/31/26: Last Week Tonight with John Oliver

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Marc Maron on ending WTF, his “nemesis” Jon Stewart and still craving validation | Wild Card

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John Oliver on the Power of Laughter & the Weight of Public Shame | Reclaiming with Monica Lewinsky

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Jamie Lee Curtis on rejecting Hollywood’s beauty standards and finally getting the roles she wants

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Anne Lamott on the radical act of embracing who you are and rejecting who others want you to be

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John C. Reilly (Full Episode) | Where Everybody Knows Your Name

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Mariska Hargitay on grieving her mom, Jayne Mansfield: ‘I’ve had a hole in my heart’

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Bob Odenkirk Would Like to Remind You That Life Is a Meaningless Farce | The Interview

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Make Hay - Private Eye on Tony Blair's intervention, SNP's shopping list and answer your qs

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Mick & Ronnie, The Rolling Stones: Tracks Of My Years - 10 songs that tell their life & career

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Jennifer Aniston & Lisa Kudrow | Actors on Actors

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'Snake oil salesman': Jeff Daniels blasts Trump, MAGA GOP enablers

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Keke Palmer, Lisa Kudrow, Hannah Einbinder & More at the THR Comedy Actress Roundtable