Pharmacology #5 - Pharmacokinetics (Drug Excretion)

Drug Excretion: Drug excretion involves processes responsible for physically removing a drug out of the body. The main organs for excretion of the drug are the liver and the kidneys. Drugs entering the hepatic circulation may also enter the bile which is then excreted into the duodenum and small intestine. Depending on the chemical properties of the drug, if the drug is not hydrophilic or polarized enough it may then reabsorb from the small intestine back into the blood circulation, this is known as the “Enterohepatic recycling”. The total medication clearance is described by the following equation CL = CLk + CLh + CLp + CLother where CLk reflects kidney clearance, CLh reflects hepatic clearance, CLp reflects pulmonary clearance if the drug is volatile and CLother integrates all other secondary sources of excretion such as breast milk, sweat, saliva, and excretion via hair follicle. However, their contribution tends to be very small. Since, kidney is the primary organ responsible for elimination of the drug, so in this tutorial we will look into the excretion of the drugs through the kidneys only. If you haven’t watched my previous videos on pharmacokinetics, please make sure to watch them first so that you have an in-depth understanding of today’s topic. Watch the video to learn more! Video (diagrams+editing) & Voiceover: Dr.Maryam Kazman Learn about Routes of Drug Administration and Bioavailability here:    • Pharmacology #1 - Routes of Drug Administr...   Learn about Drug Absorption here:    • Pharmacology #2 - Pharmacokinetics (Drug A...  Video (diagrams+editing) & Voiceover: Dr.Maryam Kazman Become a Patreon and Get Exclusive Rewards:   / dentalmaniak   Join me on Facebook: https://www.facebook.com/dentalmaniak... Instagram:  / dentalmaniak