Answers from the Experts: Q&A – February 2026

Do you have questions about cutaneous lymphoma and/or treatments? Our clinical Q&A's are a great way to learn more and empower yourself with knowledge from experts in their field. (Click on "more" for questions and timestamps.) Clinical Panel Jennifer Villasenor-Park, MD, Perelman School of Medicine, University of Pennsylvania Jasmine Zain, MD, Memorial Sloan Kettering Cancer Center Timestamps 3:12 Can mogamulizumab cause red, swollen, and peeling hands, or is this more likely a sign of disease progression? 4:57 Does electron total body beam therapy clear the skin and stay clear? 7:04 If Moga was tried, and stopped working, what is the likelihood of it working on a second try at a later date? 8:43 Can Sézary syndrome cause symptoms like watery eyes or tinnitus, or are these more likely related to something else? 10:36 Should my hematologist and dermatologist be in the same system and work together or is it ok to have them in different health systems? 131:19 I’m just starting radiation if it doesn’t work how soon can I try again? 15:21 What is your take on PD1 inhibitors on heavily pretreated patients who have previously undergone Stem cell transplant and CAR-T 17:54 My question is about early treatment options 24:05 Does consistent total body radiation to treat CTCL over the course of years cause other problems over time? 26:39 What can you do if you are on mogamulizumab for Sézary, your numbers are looking good but the itch is getting worse? 29:45 How is the body's natural surveillance system affected by MF along with rare overreactions to arachnoid like bites and potential treatment pathways, IE: like Dupixent -- though have heard some pluses and minuses with this. 33:54 Are there any emerging new treatments for Sezary syndrome? What is the status of Lacutamab? 36:16 Can you briefly re-describe the clinical trial at UPenn and the criteria for inclusion as of now? 37:39 Can one have two different types of mycosis fungoides ie. patches, plaques and follicular lymphoma? 39:26 How effective are handheld phototherapy units? I want to use one for longterm travel overseas? 41:17 I have an adverse reaction to phototherapy each session i.e.-severe itchy, red raised hives all over, and take Gabapentin and several topical lotions. Any other recommendations for relief? 43:33 When a treatment modality fails (patient shows progession), how long before you would move on to another, perhaps more aggressive therapy? 45:25 What happens when the tumors form? 48:07 Does decreasing WBC count have any prognostic value in monitoring FMF CTCL progression? 49:47 Anything really new for itching? What are some of the best creams/lotions to control itching? 52:51 In which cases do you consider interferon? 54:34 What are the survival outcomes for people with subcutaneous T cell lymphoma? 58:05 Will I have treatments indefinitely?