Lecture On Macrolides: Pharmacology, Mechanism of Action, & Clinical Uses | MBBS

This lecture covers the complete pharmacological profile of the Macrolide antibiotic group. Designed for MBBS students and those preparing for postgraduate entrance exams, this session provides a detailed breakdown of their mechanism of action, antimicrobial spectrum, pharmacokinetic properties, and clinical applications. Key Topics Covered: 00:00:00 – Introduction to Macrolides: Spectrum & Structure 00:04:42 – Mechanism of Action: Inhibition of Bacterial Protein Synthesis (50S Ribosomal Binding) 00:07:34 – Antimicrobial Spectrum: Gram-positive vs. Gram-negative Activity 00:08:46 – Resistance Mechanisms: Plasmid-mediated & Ribosomal Alteration 00:09:57 – Pharmacokinetics: Acid Lability, Distribution, & Excretion 00:10:59 – Side Effects & Clinical Interactions (CYP3A4 Inhibition) 00:12:47 – Clinical Uses of Erythromycin (Alternative to Penicillin) 00:16:35 – Newer Macrolides: Roxithromycin, Clarithromycin, Azithromycin 00:18:12 – Clarithromycin: Saturation Kinetics & Triple Drug Regimens (H. pylori) 00:21:28 – Azithromycin: Pharmacokinetics, Half-life, & Clinical Indications 00:24:57 – Spiramycin: Specialized use in Toxoplasmosis #Pharmacology #Macrolides #MBBS #Antibiotics #Azithromycin #Clarithromycin #Erythromycin #MedicalEducation #NEETPG #ClinicalPharmacology #SantiniketanMedicalCollege SANTINIKETAN MEDICAL COLLEGE & HOSPITAL Real Classroom Demonstration/Lecture On: PHARMACOLOGY by Dr. Shanwar Harlalka (MBBS Batch: (2024-25) Conducted on: 25-06-26