ÉTAPE DE TRANSITION - DU PYRUVATE A L'ACÉTYl- CoA

TRANSITION PHASE – Part 1 of 2 Define transition phase. Construct the pyruvate molecule. How do the two pyruvates enter the mitochondria? What are the general fates of acetyl-CoA? What can you tell me about the purpose of the Krebs cycle? What is the function of pyruvate dehydrogenase and decarboxylase? The transition reaction has a negative Gibbs energy; what is the significance of this? What is the structure of the pyruvate dehydrogenase complex? Define prosthetic group. What is the function of each enzyme E1, E2, and E3 of PDH? Clinical Importance: An assessment of the importance of nutrition during this transition phase Keywords and phrases: pyruvate, acetyl-CoA, mitochondria, vitamin B1 (thiamine), lipoate, vitamin B3 (niacin), vitamin B5 (pantothenic acid), NAD+, FAD, porin, pyruvate translocase, symport system, Krebs cycle, PDH (pyruvate dehydrogenase), pyruvate decarboxylase, dihydrolipoyl transacetylase, TPP (thiamine pyrophosphate), lipoamide, lipoic acid, lipoate, dihydrolipoyl dehydrogenase, Gibbs free energy, exergonic reaction, prosthetic group, heme Subjects included: Mitochondria, Glycolysis, Fermentation Anaerobic -------------------------------Correction------------------- ⚠️ Correction at 8:40 PM — I mentioned "chlorine" as the central atom of chlorophyll. It is actually magnesium (Mg²⁺). The name chlorophyll comes from the Greek word khloros (= green), not from the element chlorine.