Dr. Sia Daneshmand - Extraperitoneal RPLND & MicroRNA 371

In this episode of It Takes Balls, Dr. Sia Daneshmand, a leading urologic oncologist at USC, joins the conversation to break down the realities of testicular cancer treatment, surgery, and long-term outcomes. Known for his expertise in complex cases and extraperitoneal RPLNDs, Dr. Daneshmand shares how advances in surgery and a personalized approach to care are improving survival while reducing unnecessary treatment. The discussion dives into critical decisions patients face after diagnosis, including when surveillance vs. treatment is appropriate and how factors like tumor type, staging, and risk influence the path forward. Dr. Daneshmand explains the role of retroperitoneal lymph node dissection (RPLND), when it’s necessary, and how surgical expertise can dramatically impact outcomes and quality of life. Beyond treatment, this episode explores the importance of being treated at high-volume centers, avoiding overtreatment, and understanding the long-term effects of both surgery and chemotherapy. Dr. Daneshmand also discusses the status and future of MicroRNA 371 biomarker testing. Whether you’re newly diagnosed, considering surgery, or learning more about testicular cancer treatment options, this episode provides trusted insight from one of the leading experts in the field helping patients make informed decisions with confidence. Provide your feedback on the podcast: https://www.testicularcancerawareness... Have a question for a future expert guest? Submit here: https://www.testicularcancerawareness... Want to be a guest? Apply here: https://www.testicularcancerawareness... Follow Testicular Cancer Awareness Foundation: ⁠https://www.testescancer.org ⁠⁠   / testescancer⁠   ⁠  / testescancer   ⁠⁠   / tca.org   Dr. Daneshmand: https://keck.usc.edu/faculty-search/s...   / sia-daneshmand-m-d-569166b   https://x.com/siadaneshmand Follow Steven Crocker:   / stevencrocker     / stevencrocker     / steven.crocker2   Theme song: No Time Like Now - Tom Willner www.tomwillner.com #testicularcancer #testicularcancerawareness #testescancer #medicalpodcast #podcast #ittakesballs 00:00:00 Introduction 00:00:56 TC Landing Zone 00:03:01 Why would someone need RPLND? 00:07:45 High-volume centers 00:10:40 Retrograde ejaculation 00:14:53 EP-RPLND 00:26:40 MicroRNA 371 00:35:48 Changes in Stage 2 Management 00:39:20 Accomplishments in TC treatment