B2B Oncologia Ep.04 - O paradoxo de Warburg

In this episode of Back to Basics in Oncology, we'll understand the Warburg Effect, one of the most important concepts for understanding tumor metabolism. Why do tumor cells consume so much glucose, even when oxygen is available? Why do they choose a seemingly less efficient pathway to generate energy? And how did this metabolic behavior become one of the foundations of FDG-based PET-CT? Throughout the episode, Ana Cláudia explains how a normal cell produces energy, what changes in tumor cells, and why this "inefficiency" is actually a biological strategy: the tumor trades energy efficiency for proliferation rate, biomass production, adaptation to hypoxia, and acidification of the tumor microenvironment. We also discuss the main molecular switches involved in this process, such as MYC, PI3K/AKT, HIF-1α, and P53, and connect this knowledge to clinical practice through FDG-based PET-CT, showing how tumor metabolism can be visualized in real time. An episode to understand how biochemistry, tumor biology, and oncological diagnosis connect in practice. Check out the channel and watch all the episodes:    / @b2boncologia   📌 @b2boncologia — oncology with technical depth and clear language, for physicians, residents, and academics. #B2BOncologia #BackToBasics #Oncology #WarburgEffect #TumorMetabolism #PETCT #FDG #TumorBiology #MedicalEducation #ClinicalOncology #BrazilianPhysician #MedicalResidency #RadarB2