L-07 Non-Classical Cell Signaling Explained | Notch, Wnt, Hedgehog & TNF Receptor Pathways |

🔥 Master the Non-Classical Cell Signaling Pathways in one complete lecture! In this comprehensive lecture, Dr. Mukesh Sir (Ph.D., AIIMS) explains the four most important non-classical signaling pathways—Delta-Notch, Wnt, Hedgehog, and TNF Receptor signaling—using simple diagrams, logical explanations, and exam-oriented concepts. These pathways regulate embryonic development, stem cell maintenance, cell differentiation, immunity, apoptosis, inflammation, tissue homeostasis, and cancer, making them highly important for competitive examinations and higher education. 📖 Topics Covered 🔹 Delta-Notch Signaling Structure of Notch receptor Delta ligand interaction Proteolytic cleavage (ADAM & γ-secretase) NICD translocation CSL transcription complex Lateral inhibition Cell fate determination Clinical significance 🔹 Wnt Signaling Canonical (β-Catenin) pathway Non-Canonical Wnt pathway Frizzled receptor LRP5/6 co-receptor APC, Axin & GSK3β complex β-Catenin stabilization Target gene activation Development and cancer 🔹 Hedgehog Signaling Hedgehog ligand PTCH receptor Smoothened (SMO) GLI transcription factors Developmental regulation Disease relevance 🔹 TNF Receptor Signaling TNF-α and TNFR1/TNFR2 TRADD, TRAF & RIPK signaling NF-κB activation MAPK pathway Cell survival Apoptosis Inflammatory signaling 🎯 Best For ✅ CSIR NET Life Science ✅ GATE Biotechnology (BT) ✅ DBT BET ✅ IIT JAM Biotechnology ✅ CUET PG ✅ MSc Entrance ✅ BSc & MSc Life Sciences ✅ MBBS Biochemistry ✅ NEET PG ✅ Biotechnology ✅ Molecular Biology ✅ Cell Biology 📚 Watch the Complete Cell Signaling Series This lecture is part of the Complete Cell Signaling Playlist, covering: ✔ GPCR Signaling (Part 1 & Part 2) ✔ RTK Signaling ✔ PI3K–AKT–mTOR Pathway ✔ Non-Receptor Tyrosine Kinases (NRTKs) ✔ JAK–STAT Signaling ✔ TGF-β Signaling ✔ MAPK/ERK Pathway ✔ Notch Signaling ✔ Wnt Signaling ✔ Hedgehog Signaling ✔ TNF Receptor Signaling ✔ Complete Exam-Oriented MCQs 🌟 Why Watch This Lecture? ✔ Easy-to-understand animations ✔ High-yield concepts for competitive exams ✔ Simple explanations of complex pathways ✔ Previous year question-oriented approach ✔ Perfect for revision and concept building 👍 Support the Channel If you found this lecture helpful: 👍 Like the video 📤 Share it with your friends 🔔 Subscribe for more Biochemistry, Molecular Biology, and Life Science lectures 💬 Comment your doubts and suggestions Non-classical signaling pathways, Notch signaling, Delta Notch pathway, Wnt signaling pathway, canonical Wnt pathway, non-canonical Wnt pathway, Hedgehog signaling, Sonic Hedgehog pathway, TNF receptor signaling, TNF alpha pathway, cell signaling, signal transduction, developmental biology, molecular biology, cell biology, stem cell signaling, cancer biology, biochemistry, CSIR NET Life Science, GATE Biotechnology, DBT BET, NEET PG, MBBS Biochemistry, MSc Biotechnology, IIT JAM, CUET PG, Dr Mukesh Sir, AIIMS. 📌 Hashtags #CellSignaling #NotchSignaling #WntSignaling #HedgehogSignaling #TNFReceptor #SignalTransduction #MolecularBiology #CellBiology #Biochemistry #CSIRNET #GATEBT #DBTBET #NEETPG #MBBS #LifeScience #Biotechnology #DevelopmentalBiology #DrMukeshSir #AIIMS #HighYieldBiology #drmukeshmamgain