You're Taking NAD+ WRONG (The Science Proves It)

In this evidence-based deep dive, Dr. Kevin Joseph breaks down the real science behind NAD+ (nicotinamide adenine dinucleotide) and explains how it impacts cellular energy, DNA repair, metabolism, brain function, and longevity. You’ve probably seen celebrities getting NAD+ IV drips and clinics charging hundreds of dollars per infusion — but does it actually increase intracellular NAD+ levels? Or is most of it broken down before it ever reaches your cells? In this video, we cover: • What NAD+ does at a cellular level • How NAD+ supports mitochondrial ATP production • The role of NAD+ in DNA repair and sirtuin activation • Why NAD+ levels decline with age • The problem with NAD+ crossing cell membranes • The CD38 enzyme and why it matters • Oral NAD+ precursors (NR & NMN) vs IV NAD+ therapy • Subcutaneous NAD+ injections — is there evidence? • What clinical studies actually show about raising NAD+ levels If you're considering NAD+ IV therapy, NMN, NR, or other NAD+ supplements for anti-aging, energy, brain health, or metabolic support, this breakdown will help you understand what’s marketing — and what’s real biology. As always, I focus on the data, not the hype. If you've tried NAD+ — oral, IV, injections — drop your experience in the comments. I’m genuinely curious what people are noticing in the real world. Subscribe for more science-backed videos on longevity, peptides, metabolic health, and GLP-1 medications. Contact me: Email - [email protected] Instagram - @dr.kjoseph Supplements I personally use: Mag 07 for constipation - [https://amzn.to/43Nbe2a](https://amzn.to/43Nbe2a) Insulin syringes - [https://amzn.to/4ex2EYQ](https://amzn.to/4ex2EYQ) Electrolytes - [https://amzn.to/4lFEiOY](https://amzn.to/4lFEiOY) Creatine - [https://amzn.to/44FA3fB](https://amzn.to/44FA3fB) Pre-workout/Morning Caffeine boost - [https://amzn.to/43WGvQl](https://amzn.to/43WGvQl)