NHLBI ICTR Webinar #4: Flexible Sample Sizes

This webinar will focus on sample size adjusted based on the effect observed in the trial. Dr. Anna McGlothlin will discuss methods such a group sequential designs and goldilocks methods that account for incomplete data. She will discuss ramifications of early stopping, for example the induced multiplicities and resulting changes to control type I error as well as quantifying and minimizing any potential biases in point estimates from stopping early. The presentation will describe the benefits when the anticipated treatment effect is unknown, and thus it is desirable the trial adapt to whatever treatment effect actually emerges. This video has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract No.HHSN268201800008I. Visit the ICTR website at www.innovativeclinicaltrial.org for more videos and information!