244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee

Watch the full episode and view show notes here: http://bit.ly/3krhSr0 Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ We discuss: 0:00:00 - Intro 0:00:08 - How the cell brings the genome to life, and how Sid’s recent book fits into his prior work to tell a story 0:09:13 - How the germ theory of disease and an understanding of the cell fueled a big leap in medicine 0:18:46 - What is the evolutionary drive for multicellular life? 0:29:21 - Four types of cell therapies and the challenges of gene therapy 0:42:09 - CAR T-cell therapy: promising gene therapy for cancer 0:48:25 - The possibility of using gene therapy to treat germline mutations like sickle cell disease 0:52:54 - The incredible revolution of gene editing with CRISPR 1:02:13 - Ethical questions around human gene editing 1:14:24 - The complex role of genetics in mental illness 1:20:33 - Two types of problems in science: the “eye in the sandstorm” problem and the “sand in the eye” problem 1:23:38 - Understanding neural networks: an example of the “sand in the eye” problem being solved 1:33:16 - Importance of learning by doing: comparing the learning styles of a doctoral student to a medical student 1:38:45 - Sid’s unique and brilliant style of writing 1:44:34 - Falling as the leading cause of accidental death: a liability of multicellular existence 1:49:05 - Sid’s struggle with depression and his desire to change the stigma around mental illness -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.