Possibly the Saddest Hawaii Five 0 scene...

This scene is so tense and emotional. The episode (S1EP19 Once Upon A Time) basically in a nutshell is about how McGarretts sister, Mary's baby has cancer. McGarrett journeys to Los Angeles where he takes on Dr. C.L. Fremont, a "blood-sucking" quack "naturologist" ("one who heals by helping nature") who is treating his cancer-stricken nephew. McGarrett comes under attack from his sister, Mary Ann Whalen who thinks that Fremont is beyond criticism. McGarrett tells his sister that Fremont "couldn't cure a ham." This scene takes place after McGarrett gets the call that his nephew has died. It's really depressing.